(S)-4-isopropyl-3-[(1Z,4E)-6-(3-methoxyphenoxy)-4-methyl-3-oxo-1-phenylhexa-1,4-dien-2-yl]oxazolidin-

Base Information

Chemical Name:(S)-4-isopropyl-3-[(1Z,4E)-6-(3-methoxyphenoxy)-4-methyl-3-oxo-1-phenylhexa-1,4-dien-2-yl]oxazolidin-
CAS No.:1370641-41-0
Molecular Formula:C₂₆H₂₉NO₅
Molecular Weight:435.52
Hs Code.:

Synonyms:(S)-4-isopropyl-3-[(1Z,4E)-6-(3-methoxyphenoxy)-4-methyl-3-oxo-1-phenylhexa-1,4-dien-2-yl]oxazolidin-

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Chemical Property of (S)-4-isopropyl-3-[(1Z,4E)-6-(3-methoxyphenoxy)-4-methyl-3-oxo-1-phenylhexa-1,4-dien-2-yl]oxazolidin-

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Technology Process of (S)-4-isopropyl-3-[(1Z,4E)-6-(3-methoxyphenoxy)-4-methyl-3-oxo-1-phenylhexa-1,4-dien-2-yl]oxazolidin-

There total 6 articles about (S)-4-isopropyl-3-[(1Z,4E)-6-(3-methoxyphenoxy)-4-methyl-3-oxo-1-phenylhexa-1,4-dien-2-yl]oxazolidin- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: (S)-4-phenyl-3-(2-phenylethynyl)oxazolidin-2-one

: 1370641-47-6
(E)-4-(3'-methoxyphenoxy)-2-methyl-2-butenoyl chloride

: 1370641-41-0
(S)-4-isopropyl-3-[(1Z,4E)-6-(3-methoxyphenoxy)-4-methyl-3-oxo-1-phenylhexa-1,4-dien-2-yl]oxazolidin-

Guidance literature:: (S)-4-phenyl-3-(2-phenylethynyl)oxazolidin-2-one; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; In dichloromethane; at 0 - 20 ℃; for 0.533333h; Inert atmosphere;

(E)-4-(3'-methoxyphenoxy)-2-methyl-2-butenoyl chloride; With copper(I) thiophene-2-carboxylate; In dichloromethane; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol300316a

Reference yield:

: 932-87-6
1-Bromo-2-phenylacetylene

: 1370641-41-0
(S)-4-isopropyl-3-[(1Z,4E)-6-(3-methoxyphenoxy)-4-methyl-3-oxo-1-phenylhexa-1,4-dien-2-yl]oxazolidin-

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline; potassium carbonate / toluene / 90 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride / dichloromethane / 0.53 h / 0 - 20 °C / Inert atmosphere

2.2: Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; tri-n-butyl-tin hydride; potassium carbonate; In dichloromethane; toluene; 2.2: Stille-type cross-coupling;
DOI:10.1021/ol300316a

Reference yield:

: 150-19-6
O-methylresorcine

: 1370641-41-0
(S)-4-isopropyl-3-[(1Z,4E)-6-(3-methoxyphenoxy)-4-methyl-3-oxo-1-phenylhexa-1,4-dien-2-yl]oxazolidin-

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 3 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / Inert atmosphere

3.1: sodium hydride / diethyl ether; mineral oil / 20 °C / Inert atmosphere; Cooling with ice

3.2: 0 - 20 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride / dichloromethane / 0.53 h / 0 - 20 °C / Inert atmosphere

4.2: Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; tri-n-butyl-tin hydride; sodium hydride; potassium carbonate; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone; mineral oil; 4.2: Stille-type cross-coupling;
DOI:10.1021/ol300316a