16-carbomethoxy-20-<3-(p-toluenesulfonyloxy)propyl>-D-nordesethylcleavamine

Base Information

Chemical Name:16-carbomethoxy-20-<3-(p-toluenesulfonyloxy)propyl>-D-nordesethylcleavamine
CAS No.:110097-23-9
Molecular Formula:C₂₆H₃₂N₂O₅S
Molecular Weight:484.616
Hs Code.:

Synonyms:16-carbomethoxy-20-<3-(p-toluenesulfonyloxy)propyl>-D-nordesethylcleavamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 16-carbomethoxy-20-<3-(p-toluenesulfonyloxy)propyl>-D-nordesethylcleavamine

Chemical Property:

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Technology Process of 16-carbomethoxy-20-<3-(p-toluenesulfonyloxy)propyl>-D-nordesethylcleavamine

There total 5 articles about 16-carbomethoxy-20-<3-(p-toluenesulfonyloxy)propyl>-D-nordesethylcleavamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 109704-71-4,109784-66-9,110222-32-7,126641-15-4,126641-18-7
16-carbomethoxy-N^b-benzyl-20-(3-(p-toluenesulfonyloxy)propyl)-D-nordesethylcleavamine

: 110097-23-9
16-carbomethoxy-20-<3-(p-toluenesulfonyloxy)propyl>-D-nordesethylcleavamine

Guidance literature:: With perchloric acid; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃;
DOI:10.1021/jo00228a034

Reference yield:

: 109704-66-7,109784-64-7,126643-72-9
C₁₉H₂₄N₂O₃

: 110097-23-9
16-carbomethoxy-20-<3-(p-toluenesulfonyloxy)propyl>-D-nordesethylcleavamine

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) diisopropylethyl amine / 1.) THF, reflux, 2 h, 2.) MeOH, reflux

2: 40 percent / pyridine / 20 °C

3: 55 percent / NaBH₄, AcOH / 90 °C

4: 47 percent / HClO₄, H₂ / 10percent Pd/C / methanol / 20 °C

With pyridine; sodium tetrahydroborate; perchloric acid; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol;
DOI:10.1021/jo00228a034

Reference yield:

: 109704-68-9,126643-65-0
N^b-benzyl-20-(3-hydroxypropyl)-D-nordesethylvincadifformine

: 110097-23-9
16-carbomethoxy-20-<3-(p-toluenesulfonyloxy)propyl>-D-nordesethylcleavamine

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / pyridine / 20 °C

2: 55 percent / NaBH₄, AcOH / 90 °C

3: 47 percent / HClO₄, H₂ / 10percent Pd/C / methanol / 20 °C

With pyridine; sodium tetrahydroborate; perchloric acid; hydrogen; acetic acid; palladium on activated charcoal; In methanol;
DOI:10.1021/jo00228a034