N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-2,2-dimethyl-3-oxopropanamide

Base Information

Chemical Name:N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-2,2-dimethyl-3-oxopropanamide
CAS No.:1346764-67-7
Molecular Formula:C₁₉H₃₀ClNO₄Si
Molecular Weight:399.99
Hs Code.:

Synonyms:N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-2,2-dimethyl-3-oxopropanamide

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Chemical Property of N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-2,2-dimethyl-3-oxopropanamide

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Technology Process of N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-2,2-dimethyl-3-oxopropanamide

There total 2 articles about N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-2,2-dimethyl-3-oxopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346764-64-4
N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-2,2-dimethylbut-3-enamide

: C₁₃H₁₆ClNO₄

: 1346764-67-7
N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-2,2-dimethyl-3-oxopropanamide

Guidance literature:: N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-2,2-dimethylbut-3-enamide; With osmium(VIII) oxide; N-methylmorpholine N-oxyde; In tetrahydrofuran; water; at 30 ℃; Inert atmosphere;

With sodium periodate; In tetrahydrofuran; water; at 20 ℃;

With sodium hydrogencarbonate;

Reference yield:

: 10276-09-2
2,2-dimethyl-but-3-enoic acid

: C₁₃H₁₆ClNO₄

: 1346764-67-7
N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-2,2-dimethyl-3-oxopropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 4 h / 100 °C

1.2: -20 - 20 °C

2.1: osmium(VIII) oxide; N-methylmorpholine N-oxyde / water; tetrahydrofuran / 30 °C / Inert atmosphere

2.2: 20 °C

With osmium(VIII) oxide; thionyl chloride; N-methylmorpholine N-oxyde; In tetrahydrofuran; water;