tert-butyl-(3S,αS)-3-(N-benzyl-N-(α-methylbenzyl)amino)-7-hydroxyheptanoate

Base Information

Chemical Name:tert-butyl-(3S,αS)-3-(N-benzyl-N-(α-methylbenzyl)amino)-7-hydroxyheptanoate
CAS No.:852052-55-2
Molecular Formula:C₂₆H₃₇NO₃
Molecular Weight:411.585
Hs Code.:

Synonyms:tert-butyl-(3S,αS)-3-(N-benzyl-N-(α-methylbenzyl)amino)-7-hydroxyheptanoate

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Chemical Property of tert-butyl-(3S,αS)-3-(N-benzyl-N-(α-methylbenzyl)amino)-7-hydroxyheptanoate

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Technology Process of tert-butyl-(3S,αS)-3-(N-benzyl-N-(α-methylbenzyl)amino)-7-hydroxyheptanoate

There total 1 articles about tert-butyl-(3S,αS)-3-(N-benzyl-N-(α-methylbenzyl)amino)-7-hydroxyheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 17480-69-2
(S)-N-benzyl-1-phenylethylamine

: 117471-84-8
1,1-dimethylethyl (E)-7-hydroxyhept-2-enoate

: 852052-55-2
tert-butyl-(3S,αS)-3-(N-benzyl-N-(α-methylbenzyl)amino)-7-hydroxyheptanoate

Guidance literature:: (S)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

1,1-dimethylethyl (E)-7-hydroxyhept-2-enoate; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1039/b500223k

Reference yield: 91.0%

: 852052-55-2
tert-butyl-(3S,αS)-3-(N-benzyl-N-(α-methylbenzyl)amino)-7-hydroxyheptanoate

: 852052-41-6
tert-butyl (3S,αS)-3-(N-benzyl-N-(α-methylbenzyl)amino)-7-oxoheptanoate

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃; for 1.33333h;
DOI:10.1039/b500223k

Reference yield:

: 852052-55-2
tert-butyl-(3S,αS)-3-(N-benzyl-N-(α-methylbenzyl)amino)-7-hydroxyheptanoate

: (1R,2S,6S)-2-acetoxy-6-aminocyclohexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 1.33 h / -78 - 20 °C

2: 94 percent / pyridine; DMAP / CH₂Cl₂ / 16 h / 20 °C

3: 96 percent / H₂ / Pd(OH)2/C / methanol / 16 h / 3800 Torr

4: 84 percent / TFA / CH₂Cl₂ / 16 h / 20 °C

With pyridine; dmap; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; palladium dihydroxide; In methanol; dichloromethane; 1: Swern oxidation;
DOI:10.1039/b500223k