5-{[(1S,2R,3S,4aS,8aS)-3-(1H-imidazol-1-ylmethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]carbonyl}benzene-1,3-diol

Base Information

Chemical Name:5-{[(1S,2R,3S,4aS,8aS)-3-(1H-imidazol-1-ylmethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]carbonyl}benzene-1,3-diol
CAS No.:1619983-43-5
Molecular Formula:C₂₅H₃₄N₂O₃
Molecular Weight:410.557
Hs Code.:

Synonyms:5-{[(1S,2R,3S,4aS,8aS)-3-(1H-imidazol-1-ylmethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]carbonyl}benzene-1,3-diol

Suppliers and Price of 5-{[(1S,2R,3S,4aS,8aS)-3-(1H-imidazol-1-ylmethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]carbonyl}benzene-1,3-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-{[(1S,2R,3S,4aS,8aS)-3-(1H-imidazol-1-ylmethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]carbonyl}benzene-1,3-diol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-{[(1S,2R,3S,4aS,8aS)-3-(1H-imidazol-1-ylmethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]carbonyl}benzene-1,3-diol

There total 12 articles about 5-{[(1S,2R,3S,4aS,8aS)-3-(1H-imidazol-1-ylmethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]carbonyl}benzene-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1619983-42-4
1-{[(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methyl}-1H-imidazole

: 1619983-43-5
5-{[(1S,2R,3S,4aS,8aS)-3-(1H-imidazol-1-ylmethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]carbonyl}benzene-1,3-diol

Guidance literature:: 1-{[(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methyl}-1H-imidazole; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 21h; Inert atmosphere;

With hydrogenchloride; In water; isopropyl alcohol; at 85 ℃; for 0.75h;

Reference yield:

: 1619983-08-2
[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](3,5-dimethoxyphenyl)methanone

: 1619983-43-5
5-{[(1S,2R,3S,4aS,8aS)-3-(1H-imidazol-1-ylmethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]carbonyl}benzene-1,3-diol

Guidance literature:: Multi-step reaction with 8 steps

1.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere

1.2: 1.33 h / 0 - 65 °C

2.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; methanol / 3.5 h / 80 °C

4.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.2: 2 h

5.1: borane-THF / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

5.2: 2 h / 20 °C / Cooling with ice

6.1: pyridine / 1.5 h / Cooling with ice; Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / Cooling with ice; Inert atmosphere

7.2: 17 h / 20 °C / Cooling with ice

8.1: boron tribromide / dichloromethane / 21 h / -78 - 20 °C / Inert atmosphere

8.2: 0.75 h / 85 °C

With pyridine; borane-THF; potassium tert-butylate; boron tribromide; sodium hydride; pyridinium chlorochromate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; 4.1: |Wittig Olefination;

Reference yield:

: (1S,2R,4aS,8aS)-1-[(3,5-dimethoxyphenyl)(hydroxy)methyl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

: 1619983-43-5
5-{[(1S,2R,3S,4aS,8aS)-3-(1H-imidazol-1-ylmethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]carbonyl}benzene-1,3-diol

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C

2.1: tin(IV) chloride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere

3.2: 1.33 h / 0 - 65 °C

4.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C

5.1: sodium hydroxide / tetrahydrofuran; methanol / 3.5 h / 80 °C

6.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

6.2: 2 h

7.1: borane-THF / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

7.2: 2 h / 20 °C / Cooling with ice

8.1: pyridine / 1.5 h / Cooling with ice; Inert atmosphere

9.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / Cooling with ice; Inert atmosphere

9.2: 17 h / 20 °C / Cooling with ice

10.1: boron tribromide / dichloromethane / 21 h / -78 - 20 °C / Inert atmosphere

10.2: 0.75 h / 85 °C

With pyridine; borane-THF; potassium tert-butylate; boron tribromide; tin(IV) chloride; sodium hydride; pyridinium chlorochromate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; 6.1: |Wittig Olefination;