(R)-2-((R)-2-{(R)-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-hydroxy-methyl}-3-methyl-cyclopent-2-enyl)-propionaldehyde

Base Information

• Chemical Name: (R)-2-((R)-2-{(R)-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-hydroxy-methyl}-3-methyl-cyclopent-2-enyl)-propionaldehyde
• CAS No.: 120354-76-9
• Molecular Formula: C₂₇H₃₈O₃
• Molecular Weight: 410.597

Synonyms:(R)-2-((R)-2-{(R)-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-hydroxy-methyl}-3-methyl-cyclopent-2-enyl)-propionaldehyde

Chemical Property of (R)-2-((R)-2-{(R)-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-hydroxy-methyl}-3-methyl-cyclopent-2-enyl)-propionaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-((R)-2-{(R)-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-hydroxy-methyl}-3-methyl-cyclopent-2-enyl)-propionaldehyde

There total 8 articles about (R)-2-((R)-2-{(R)-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-hydroxy-methyl}-3-methyl-cyclopent-2-enyl)-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-2-((R)-2-{(R)-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-trimethylsilanyloxy-methyl}-3-methyl-cyclopent-2-enyl)-propionaldehyde (120410-10-8) → (R)-2-((R)-2-{(R)-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-hydroxy-methyl}-3-methyl-cyclopent-2-enyl)-propionaldehyde (120354-76-9)

Guidance literature:

With pyridinium p-toluenesulfonate; In tetrahydrofuran; water; for 48h;

Reference yield:

(3S,8R)-9-benzyloxy-7-chloroirid-1-ene (93178-06-4) → (R)-2-((R)-2-{(R)-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-hydroxy-methyl}-3-methyl-cyclopent-2-enyl)-propionaldehyde (120354-76-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 88 percent / CrCl₂ / tetrahydrofuran; dimethylformamide; propan-2-ol

2: pyridine

3: 2CHCH(Me)>2BH, H₂O₂/OH^(1-)

4: pyridinium chlorochromate / CH₂Cl₂

5: 90 percent / KF-Florisil / methanol

6: 100 percent / pyridinium toluene-p-sulphonate / tetrahydrofuran; H₂O

With pyridine; chromium dichloride; potassium fluoride; florisil; hydroxide; dihydrogen peroxide; pyridinium p-toluenesulfonate; bis-(1,2-dimethylpropyl)borane; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1039/c39880000354

Reference yield:

(R)-2-methyl-5-(prop-1-en-2-yl)cyclopent-1-ene-1-carbaldehyde (3865-09-6,38231-11-7,83945-83-9,93221-52-4) → (R)-2-((R)-2-{(R)-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-hydroxy-methyl}-3-methyl-cyclopent-2-enyl)-propionaldehyde (120354-76-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 88 percent / CrCl₂ / tetrahydrofuran; dimethylformamide; propan-2-ol

2: pyridine

3: 2CHCH(Me)>2BH, H₂O₂/OH^(1-)

4: pyridinium chlorochromate / CH₂Cl₂

5: 90 percent / KF-Florisil / methanol

6: 100 percent / pyridinium toluene-p-sulphonate / tetrahydrofuran; H₂O

With pyridine; chromium dichloride; potassium fluoride; florisil; hydroxide; dihydrogen peroxide; pyridinium p-toluenesulfonate; bis-(1,2-dimethylpropyl)borane; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1039/c39880000354

upstream raw materials:

(R)-2-((R)-2-{(R)-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-trimethylsilanyloxy-methyl}-3-methyl-cyclopent-2-enyl)-propionaldehyde

(3S,8R)-9-benzyloxy-7-chloroirid-1-ene

[(R)-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-((R)-5-isopropenyl-2-methyl-cyclopent-1-enyl)-methoxy]-trimethyl-silane

(R)-2-methyl-5-(prop-1-en-2-yl)cyclopent-1-ene-1-carbaldehyde

Downstream raw materials:

{(1R,3R,4R,4aR)-1-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-4,7-dimethyl-1,3,4,4a,5,6-hexahydro-cyclopenta[c]pyran-3-yloxy}-trimethyl-silane

{(1R,3S,4R,4aR)-1-[(1R,3S)-3-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methyl-2-methylene-cyclopentyl]-4,7-dimethyl-1,3,4,4a,5,6-hexahydro-cyclopenta[c]pyran-3-yloxy}-trimethyl-silane

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