(8S,9S,E)-8-(dimethyl(phenyl)silyl)-10-methoxy-6-methyldec-6-ene-1,9-diol

Base Information

Chemical Name:(8S,9S,E)-8-(dimethyl(phenyl)silyl)-10-methoxy-6-methyldec-6-ene-1,9-diol
CAS No.:1404098-79-8
Molecular Formula:C₂₀H₃₄O₃Si
Molecular Weight:350.574
Hs Code.:

Synonyms:(8S,9S,E)-8-(dimethyl(phenyl)silyl)-10-methoxy-6-methyldec-6-ene-1,9-diol

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Chemical Property of (8S,9S,E)-8-(dimethyl(phenyl)silyl)-10-methoxy-6-methyldec-6-ene-1,9-diol

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Technology Process of (8S,9S,E)-8-(dimethyl(phenyl)silyl)-10-methoxy-6-methyldec-6-ene-1,9-diol

There total 1 articles about (8S,9S,E)-8-(dimethyl(phenyl)silyl)-10-methoxy-6-methyldec-6-ene-1,9-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 821-09-0
n-Pent-4-enyl alcohol

: 1404098-74-3
(2S,3S)-3-(dimethyl(phenyl)silyl)-1-methoxyhex-4-yn-2-ol

: C₁₅H₂₄O₂Si

: C₃₀H₄₆O₄Si₂

: 1404098-79-8
(8S,9S,E)-8-(dimethyl(phenyl)silyl)-10-methoxy-6-methyldec-6-ene-1,9-diol

: C₂₀H₃₄O₃Si

: C₂₀H₃₄O₃Si

Guidance literature:: (2S,3S)-3-(dimethyl(phenyl)silyl)-1-methoxyhex-4-yn-2-ol; With triisopropoxytitanium(IV) chloride; n-butyllithium; cyclopentylmagnesium chloride; In diethyl ether; hexane; at -78 - 0 ℃; for 2h; Inert atmosphere;

n-Pent-4-enyl alcohol; With n-butyllithium; In diethyl ether; hexane; at -78 - 0 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja3083945

Reference yield: 75.0%

: 1404098-79-8
(8S,9S,E)-8-(dimethyl(phenyl)silyl)-10-methoxy-6-methyldec-6-ene-1,9-diol

: 1404099-06-4
(8S,9S,E)-87-(dimethyl(phenyl)silyl)-9-hydroxy-10-methoxy-6-methyldec-6-enal

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 7h; Inert atmosphere;
DOI:10.1021/ja3083945

Reference yield:

: 1404098-79-8
(8S,9S,E)-8-(dimethyl(phenyl)silyl)-10-methoxy-6-methyldec-6-ene-1,9-diol

: (S)-1-((2S,3R,3aS,7aS)-3-(dimethyl(phenyl)silyl)-3a-methyloctahydrobenzofuran-2-yl)-2-methoxyethanol

Guidance literature:: Multi-step reaction with 2 steps

1: [bis(acetoxy)iodo]benzene; 2,2,6,6-tetramethyl-piperidine-N-oxyl / dichloromethane / 7 h / 20 °C / Inert atmosphere

2: boron trifluoride diethyl etherate / dichloromethane / -40 - -30 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1021/ja3083945