tert-butyl 4-((2-(biphenyl-4-yl)-3-phenylpropanamido)methyl)benzylcarbamate

Base Information

Chemical Name:tert-butyl 4-((2-(biphenyl-4-yl)-3-phenylpropanamido)methyl)benzylcarbamate
CAS No.:1423167-45-6
Molecular Formula:C₃₄H₃₆N₂O₃
Molecular Weight:520.671
Hs Code.:

Synonyms:tert-butyl 4-((2-(biphenyl-4-yl)-3-phenylpropanamido)methyl)benzylcarbamate

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Chemical Property of tert-butyl 4-((2-(biphenyl-4-yl)-3-phenylpropanamido)methyl)benzylcarbamate

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Technology Process of tert-butyl 4-((2-(biphenyl-4-yl)-3-phenylpropanamido)methyl)benzylcarbamate

There total 5 articles about tert-butyl 4-((2-(biphenyl-4-yl)-3-phenylpropanamido)methyl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1423167-31-0
2-(biphenyl-4-yl)-3-phenylpropanoic acid

: 108468-00-4
tert-butyl 4-(aminomethyl)benzylcarbamate

: 1423167-45-6
tert-butyl 4-((2-(biphenyl-4-yl)-3-phenylpropanamido)methyl)benzylcarbamate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm301127x

Reference yield:

: 66389-80-8
tert-butyl N-[(4-cyanophenyl)methyl]carbamate

: 1423167-45-6
tert-butyl 4-((2-(biphenyl-4-yl)-3-phenylpropanamido)methyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 49 h / 0 - 20 °C / Inert atmosphere

1.2: 0.25 h / 0 °C / Inert atmosphere

2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm301127x

Reference yield:

: 10406-25-4
4-aminobenzyl cyanide

: 1423167-45-6
tert-butyl 4-((2-(biphenyl-4-yl)-3-phenylpropanamido)methyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 49 h / 0 - 20 °C / Inert atmosphere

2.2: 0.25 h / 0 °C / Inert atmosphere

3.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm301127x