(S)-2-(1H-benzo[d]imidazol-5-yl)-3-(3,4-dimethoxyphenyl)isoindolin-1-one

Base Information

Chemical Name:(S)-2-(1H-benzo[d]imidazol-5-yl)-3-(3,4-dimethoxyphenyl)isoindolin-1-one
CAS No.:1276024-43-1
Molecular Formula:C₂₃H₁₉N₃O₃
Molecular Weight:385.422
Hs Code.:

Synonyms:(S)-2-(1H-benzo[d]imidazol-5-yl)-3-(3,4-dimethoxyphenyl)isoindolin-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(1H-benzo[d]imidazol-5-yl)-3-(3,4-dimethoxyphenyl)isoindolin-1-one

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Technology Process of (S)-2-(1H-benzo[d]imidazol-5-yl)-3-(3,4-dimethoxyphenyl)isoindolin-1-one

There total 3 articles about (S)-2-(1H-benzo[d]imidazol-5-yl)-3-(3,4-dimethoxyphenyl)isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1276027-05-4
(S)-3-(3,4-dimethoxyphenyl)isoindolin-1-one

: 21304-38-1
4-iodobenzene-1,2-diamine

: 122-51-0
orthoformic acid triethyl ester

: 1276024-43-1
(S)-2-(1H-benzo[d]imidazol-5-yl)-3-(3,4-dimethoxyphenyl)isoindolin-1-one

Guidance literature:: (S)-3-(3,4-dimethoxyphenyl)isoindolin-1-one; 4-iodobenzene-1,2-diamine; With rac-diaminocyclohexane; cesium fluoride; copper(l) iodide; In 1,4-dioxane; at 95 ℃; Inert atmosphere;

orthoformic acid triethyl ester; for 2h; Reflux;

Reference yield:

: 4122-56-9
methyl o-formylbenzoate

: 1276024-43-1
(S)-2-(1H-benzo[d]imidazol-5-yl)-3-(3,4-dimethoxyphenyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetraethoxy orthosilicate / 6 h / Reflux

2.1: (3aS,6aS)-3,6-diphenyl-1,3a,4,6a-tetra-hydropentalen / chlorobis(ethylene)rhodium(I) dimer / toluene / 1 h / 55 °C / Inert atmosphere

2.2: 5 h

2.3: 1 h / 0 °C

3.1: cesium fluoride; rac-diaminocyclohexane / copper(l) iodide / 1,4-dioxane / 95 °C / Inert atmosphere

3.2: 2 h / Reflux

With tetraethoxy orthosilicate; (3aS,6aS)-3,6-diphenyl-1,3a,4,6a-tetra-hydropentalen; rac-diaminocyclohexane; cesium fluoride; copper(l) iodide; chlorobis(ethylene)rhodium(I) dimer; In 1,4-dioxane; toluene;

Reference yield:

: 940280-76-2
methyl-2-((tosylimino)methyl)benzoate

: 1276024-43-1
(S)-2-(1H-benzo[d]imidazol-5-yl)-3-(3,4-dimethoxyphenyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: (3aS,6aS)-3,6-diphenyl-1,3a,4,6a-tetra-hydropentalen / chlorobis(ethylene)rhodium(I) dimer / toluene / 1 h / 55 °C / Inert atmosphere

1.2: 5 h

1.3: 1 h / 0 °C

2.1: cesium fluoride; rac-diaminocyclohexane / copper(l) iodide / 1,4-dioxane / 95 °C / Inert atmosphere

2.2: 2 h / Reflux

With (3aS,6aS)-3,6-diphenyl-1,3a,4,6a-tetra-hydropentalen; rac-diaminocyclohexane; cesium fluoride; copper(l) iodide; chlorobis(ethylene)rhodium(I) dimer; In 1,4-dioxane; toluene;