4-Amino-5-chloro-2-ethoxy-N-[4-(1-phenyl-ethyl)-morpholin-2-ylmethyl]-benzamide

Base Information

Chemical Name:4-Amino-5-chloro-2-ethoxy-N-[4-(1-phenyl-ethyl)-morpholin-2-ylmethyl]-benzamide
CAS No.:112886-38-1
Molecular Formula:C₂₂H₂₈ClN₃O₃
Molecular Weight:417.936
Hs Code.:

Synonyms:4-Amino-5-chloro-2-ethoxy-N-[4-(1-phenyl-ethyl)-morpholin-2-ylmethyl]-benzamide

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Chemical Property of 4-Amino-5-chloro-2-ethoxy-N-[4-(1-phenyl-ethyl)-morpholin-2-ylmethyl]-benzamide

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Technology Process of 4-Amino-5-chloro-2-ethoxy-N-[4-(1-phenyl-ethyl)-morpholin-2-ylmethyl]-benzamide

There total 6 articles about 4-Amino-5-chloro-2-ethoxy-N-[4-(1-phenyl-ethyl)-morpholin-2-ylmethyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112913-96-9
2-(N-acetylaminomethyl)-4-benzylmorpholine

: 112886-38-1
4-Amino-5-chloro-2-ethoxy-N-[4-(1-phenyl-ethyl)-morpholin-2-ylmethyl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂, AcOH / 10percent Pd/C / ethanol / 60 °C

2: K₂CO₃, KI / butan-2-one / 17 h / Heating

3: 10percent HCl / 4 h / Heating

4: 1-ethyl-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With hydrogenchloride; hydrogen; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; palladium on activated charcoal; In ethanol; dichloromethane; butanone;
DOI:10.1021/jm00106a023

Reference yield:

: 4093-28-1
methyl 4-acetamido-2-hydroxybenzoate

: 112886-38-1
4-Amino-5-chloro-2-ethoxy-N-[4-(1-phenyl-ethyl)-morpholin-2-ylmethyl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / K₂CO₃ / dimethylformamide / 6 h / 50 °C

2: 97 percent / N-chlorosuccinimide (NCS) / dimethylformamide / 2 h / 70 °C

3: 99 percent / NaOH, H₂O / ethanol / 5 h / Heating

4: 1-ethyl-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With sodium hydroxide; N-chloro-succinimide; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00106a023

Reference yield:

: 59-06-3
methyl 4-acetamido-2-ethoxybenzoate

: 112886-38-1
4-Amino-5-chloro-2-ethoxy-N-[4-(1-phenyl-ethyl)-morpholin-2-ylmethyl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / N-chlorosuccinimide (NCS) / dimethylformamide / 2 h / 70 °C

2: 99 percent / NaOH, H₂O / ethanol / 5 h / Heating

3: 1-ethyl-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With sodium hydroxide; N-chloro-succinimide; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00106a023