(S)-(-)-Methyl 2-[(tert-butoxycarbonyl)amino]-6-hydroxypentanoate

Base Information

• Chemical Name: (S)-(-)-Methyl 2-[(tert-butoxycarbonyl)amino]-6-hydroxypentanoate
• CAS No.: 81505-49-9
• Molecular Formula: C₁₂H₂₃NO₅
• Molecular Weight: 261.318
• Hs Code.: 2924297099

Synonyms:(S)-(-)-Methyl 2-[(tert-butoxycarbonyl)amino]-6-hydroxypentanoate

Chemical Property of (S)-(-)-Methyl 2-[(tert-butoxycarbonyl)amino]-6-hydroxypentanoate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-6-hydroxy-DL-norleucineMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(-)-Methyl 2-[(tert-butoxycarbonyl)amino]-6-hydroxypentanoate

There total 27 articles about (S)-(-)-Methyl 2-[(tert-butoxycarbonyl)amino]-6-hydroxypentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C26H43NO7Si → (S)-(-)-Methyl 2-[(tert-butoxycarbonyl)amino]-6-hydroxypentanoate (81505-49-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 19h;

DOI:10.1002/chem.201900289

Reference yield: 97.0%

(E)-(S)-2-tert-Butoxycarbonylamino-6-hydroxy-hex-4-enoic acid methyl ester (110579-52-7) → (S)-(-)-Methyl 2-[(tert-butoxycarbonyl)amino]-6-hydroxypentanoate (81505-49-9)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethyl acetate;

DOI:10.1016/j.tetlet.2007.09.165

Reference yield: 95.0%

methyl (S)-2-(tert-butoxycarbonylamino)-6-(trifluoroacetoxy)hexanoate + methyl (S)-6-(tert-butoxy)-2-(tert-butoxycarbonylamino)hexanoate → (S)-(-)-Methyl 2-[(tert-butoxycarbonyl)amino]-6-hydroxypentanoate (81505-49-9)

Guidance literature:

With water; sodium hydrogencarbonate; In methanol; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2015.07.045

upstream raw materials:

N,N’-diisopropyl-O-methylisourea

(D,L)-N-Boc-ε-hydroxynorleucine

rac-6-hydroxynorleucine

di-tert-butyl dicarbonate

Downstream raw materials:

(S)-2-amino-6-hydroxy-hexanoic acid methyl ester

N²,N²-(1,5-citryl)bis6-acetyl-N⁶-(benzyloxy)-(L)-lysine>

N²,N²-(anhydromethylene-1,5-citryl)bis6-acetyl-N⁶-(benzyloxy)-(L)-lysine methyl ester

6-(Acetyl-benzyloxy-amino)-2-amino-hexanoic acid methyl ester

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