(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,4R)-4-tert-butyl-2,2-dimethyl-cyclohexyl ester

Base Information

• Chemical Name: (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,4R)-4-tert-butyl-2,2-dimethyl-cyclohexyl ester
• CAS No.: 73368-34-0
• Molecular Formula: C₂₂H₃₁F₃O₃
• Molecular Weight: 400.482
• Mol file: 73368-34-0.mol

Synonyms:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,4R)-4-tert-butyl-2,2-dimethyl-cyclohexyl ester

Chemical Property of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,4R)-4-tert-butyl-2,2-dimethyl-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,4R)-4-tert-butyl-2,2-dimethyl-cyclohexyl ester

There total 6 articles about (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,4R)-4-tert-butyl-2,2-dimethyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-(+)-2,2-Dimethyl-4-(2-bromo-2-propyl)cyclohexanone (73368-32-8) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,4R)-4-tert-butyl-2,2-dimethyl-cyclohexyl ester (73368-34-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 272 mg / NaBH₄ / methanol / 0.42 h / 5 °C

2: 57 percent / CHCl₃ / 3 h / Heating

3: pyridine / CCl₄ / 24 h / Ambient temperature

With pyridine; sodium tetrahydroborate; In methanol; tetrachloromethane; chloroform;

DOI:10.1021/jo01300a006

Reference yield:

3,3,6,6-tetramethylbicyclo[3.1.1]heptan-2-one (36203-40-4) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,4R)-4-tert-butyl-2,2-dimethyl-cyclohexyl ester (73368-34-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 17 percent / 450 °C

2: 46 percent / zinc dust, cuprous chloride / diethyl ether / 24 h / Heating

3: 61 mg / H₂ / PtO₂ / acetic acid / 760 Torr / Ambient temperature

4: pyridine / CCl₄ / 24 h / Ambient temperature

With pyridine; hydrogen; copper(l) chloride; zinc; platinum(IV) oxide; In tetrachloromethane; diethyl ether; acetic acid;

DOI:10.1021/jo01300a006

Reference yield:

(R)-(+)-2,2-Dimethyl-4-isopropenylcyclohexanone (69153-91-9) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,4R)-4-tert-butyl-2,2-dimethyl-cyclohexyl ester (73368-34-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 46 percent / zinc dust, cuprous chloride / diethyl ether / 24 h / Heating

2: 61 mg / H₂ / PtO₂ / acetic acid / 760 Torr / Ambient temperature

3: pyridine / CCl₄ / 24 h / Ambient temperature

With pyridine; hydrogen; copper(l) chloride; zinc; platinum(IV) oxide; In tetrachloromethane; diethyl ether; acetic acid;

DOI:10.1021/jo01300a006

upstream raw materials:

(1R,4R)-(+)-2,2-Dimethyl-4-tert-butylcyclohexan-1-ol

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

3,3,6,6-tetramethylbicyclo[3.1.1]heptan-2-one

(R)-(+)-2,2-Dimethyl-4-isopropenylcyclohexanone