N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(4,4'-dimethoxytrityl)-L-serine 6-hydroxyhexylamide

Base Information

Chemical Name:N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(4,4'-dimethoxytrityl)-L-serine 6-hydroxyhexylamide
CAS No.:815582-34-4
Molecular Formula:C₄₅H₄₈N₂O₇
Molecular Weight:728.885
Hs Code.:

Synonyms:N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(4,4'-dimethoxytrityl)-L-serine 6-hydroxyhexylamide

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Chemical Property of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(4,4'-dimethoxytrityl)-L-serine 6-hydroxyhexylamide

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Technology Process of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(4,4'-dimethoxytrityl)-L-serine 6-hydroxyhexylamide

There total 4 articles about N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(4,4'-dimethoxytrityl)-L-serine 6-hydroxyhexylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 815582-33-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(4,4'-dimethoxytrityl)-L-serine pentafluorophenyl ester

: 4048-33-3
6-amino-1-hexanol

: 815582-34-4
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(4,4'-dimethoxytrityl)-L-serine 6-hydroxyhexylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jo0485177

Reference yield:

: 73724-45-5
N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

: 815582-34-4
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(4,4'-dimethoxytrityl)-L-serine 6-hydroxyhexylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / pyridine / 20 °C

2: N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 4 h / 20 °C

3: 57 percent / N,N-diisopropyl(ethyl)amine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jo0485177

Reference yield:

: 151901-83-6
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(4,4'-dimethoxytrityl)-L-serine

: 815582-34-4
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(4,4'-dimethoxytrityl)-L-serine 6-hydroxyhexylamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 4 h / 20 °C

2: 57 percent / N,N-diisopropyl(ethyl)amine / CH₂Cl₂ / 3 h / 20 °C

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jo0485177