2,5-Bis(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole

Base Information

Chemical Name:2,5-Bis(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole
CAS No.:307557-48-8
Molecular Formula:C₁₄H₄Cl₄F₂N₂O
Molecular Weight:396.007
Hs Code.:
NSC Number:726618
DSSTox Substance ID:DTXSID30441265
Nikkaji Number:J1.461.944E
Wikidata:Q82257967
ChEMBL ID:CHEMBL2270328
Mol file:307557-48-8.mol

Synonyms:307557-48-8;2,5-BIS(2,4-DICHLORO-5-FLUOROPHENYL)-1,3,4-OXADIAZOLE;noxadiazoles;CHEMBL2270328;DTXSID30441265;NSC726618;NSC-726618

Suppliers and Price of 2,5-Bis(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2,5-BIS(2,4-DICHLORO-5-FLUOROPHENYL)-1,3,4-OXADIAZOLE 95.00%
5MG
$ 501.46

Total 3 raw suppliers

Chemical Property of 2,5-Bis(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole

Chemical Property:

Boiling Point:489.7±55.0 °C(Predicted)
PKA:-7.63±0.50(Predicted)
PSA：38.92000
Density:1.613±0.06 g/cm3(Predicted)
LogP:6.29540
XLogP3:5.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:395.901630
Heavy Atom Count:23
Complexity:388

Purity/Quality:

99% ^*data from raw suppliers

2,5-BIS(2,4-DICHLORO-5-FLUOROPHENYL)-1,3,4-OXADIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=CC(=C1F)Cl)Cl)C2=NN=C(O2)C3=CC(=C(C=C3Cl)Cl)F

Technology Process of 2,5-Bis(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole

There total 2 articles about 2,5-Bis(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 86522-89-6
2,4-dichloro-5-fluoro-benzoic acid

: 307557-48-8
2,5-Bis(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole

Guidance literature:: With 2-(4-fluorophenoxy)acetic acid hydrazide; trichlorophosphate; for 5h; Heating;
DOI:10.1016/S0022-1139(00)00323-7

Reference yield:

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 307557-48-8
2,5-Bis(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / chlorine; sodium hydroxide / ethanol / pH 10

2: 75 percent / phosphorus oxychloride / 6 h / 100 - 110 °C

With sodium hydroxide; chlorine; trichlorophosphate; In ethanol;