(5S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-ethyl-N,N-dimethyl-L-prolinamide

Base Information

Chemical Name:(5S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-ethyl-N,N-dimethyl-L-prolinamide
CAS No.:1443977-65-8
Molecular Formula:C₃₁H₃₆Cl₂N₄O₂S
Molecular Weight:599.624
Hs Code.:

Synonyms:(5S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-ethyl-N,N-dimethyl-L-prolinamide

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Chemical Property of (5S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-ethyl-N,N-dimethyl-L-prolinamide

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Technology Process of (5S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-ethyl-N,N-dimethyl-L-prolinamide

There total 10 articles about (5S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-ethyl-N,N-dimethyl-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1033710-21-2
C₂₂H₁₉Cl₃N₂OS

: 1443977-76-1
(5S)-5-ethyl-N,N-dimethyl-L-prolinamide hydrochloride

: 1443977-65-8
(5S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-ethyl-N,N-dimethyl-L-prolinamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h; Cooling with ice;
DOI:10.1016/j.bmc.2013.04.056

Reference yield:

: 1443977-75-0
C₁₄H₂₆N₂O₃

: 1443977-65-8
(5S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-ethyl-N,N-dimethyl-L-prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 50 °C

2: triethylamine / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.bmc.2013.04.056

Reference yield:

: 1033707-13-9
(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylic acid

: 1443977-65-8
(5S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-ethyl-N,N-dimethyl-L-prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / toluene / 0.5 h / 70 °C

2: triethylamine / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmc.2013.04.056