(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine

Base Information

Chemical Name:(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine
CAS No.:149655-33-4
Molecular Formula:C₁₄H₂₁NO
Molecular Weight:219.327
Hs Code.:

Synonyms:(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine

Suppliers and Price of (3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine

There total 13 articles about (3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 951240-65-6
C₁₀H₁₈NO₂SBr

: 149655-33-4
(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / Pd(Ph₃P)4 / ethanol; toluene; H₂O / 0.75 h / 80 °C

2.1: anisole; triflic acid / CH₂Cl₂ / 0.5 h / 0 °C

3.1: sodium cyanoborohydride / acetonitrile; H₂O / 0.5 h

4.1: n-butyllithium / tetrahydrofuran / -15 °C

4.2: tetrahydrofuran / -50 °C

5.1: sodium borohydride / methanol

6.1: phenyl chloroformate / toluene

With sodium tetrahydroborate; n-butyllithium; trifluorormethanesulfonic acid; sodium cyanoborohydride; sodium carbonate; methoxybenzene; phenyl chloroformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; acetonitrile; 1.1: Suzuki coupling;
DOI:10.1021/ol0713988

Reference yield:

: 951240-63-4
C₉H₁₆NO₃SBr

: 149655-33-4
(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2.5 h / 0 - 20 °C

2.1: CuBr*SMe₂ / tetrahydrofuran; diethyl ether / -40 - -35 °C

3.1: sodium carbonate / Pd(Ph₃P)4 / ethanol; toluene; H₂O / 0.75 h / 80 °C

4.1: anisole; triflic acid / CH₂Cl₂ / 0.5 h / 0 °C

5.1: sodium cyanoborohydride / acetonitrile; H₂O / 0.5 h

6.1: n-butyllithium / tetrahydrofuran / -15 °C

6.2: tetrahydrofuran / -50 °C

7.1: sodium borohydride / methanol

8.1: phenyl chloroformate / toluene

With dmap; sodium tetrahydroborate; n-butyllithium; copper(I) bromide dimethylsulfide complex; trifluorormethanesulfonic acid; sodium cyanoborohydride; sodium carbonate; methoxybenzene; triethylamine; phenyl chloroformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; toluene; acetonitrile; 2.1: Grignard reaction / 3.1: Suzuki coupling;
DOI:10.1021/ol0713988

Reference yield:

: 951240-64-5
C₁₃H₂₅NO₆SBrP

: 149655-33-4
(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: CuBr*SMe₂ / tetrahydrofuran; diethyl ether / -40 - -35 °C

2.1: sodium carbonate / Pd(Ph₃P)4 / ethanol; toluene; H₂O / 0.75 h / 80 °C

3.1: anisole; triflic acid / CH₂Cl₂ / 0.5 h / 0 °C

4.1: sodium cyanoborohydride / acetonitrile; H₂O / 0.5 h

5.1: n-butyllithium / tetrahydrofuran / -15 °C

5.2: tetrahydrofuran / -50 °C

6.1: sodium borohydride / methanol

7.1: phenyl chloroformate / toluene

With sodium tetrahydroborate; n-butyllithium; copper(I) bromide dimethylsulfide complex; trifluorormethanesulfonic acid; sodium cyanoborohydride; sodium carbonate; methoxybenzene; phenyl chloroformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; toluene; acetonitrile; 1.1: Grignard reaction / 2.1: Suzuki coupling;
DOI:10.1021/ol0713988