3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-1-propanesulfonic acid

Base Information

Chemical Name:3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-1-propanesulfonic acid
CAS No.:1345982-59-3
Molecular Formula:C₂₅H₃₅NO₆S₂
Molecular Weight:509.688
Hs Code.:

Synonyms:3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-1-propanesulfonic acid

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Chemical Property of 3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-1-propanesulfonic acid

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Technology Process of 3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-1-propanesulfonic acid

There total 9 articles about 3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-1-propanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1345983-56-3
(3R,5R)-8-(3-bromopropyl)-3-butyl-3-ethyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepine 1,1-dioxide

: 1345982-59-3
3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-1-propanesulfonic acid

Guidance literature:: (3R,5R)-8-(3-bromopropyl)-3-butyl-3-ethyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepine 1,1-dioxide; With sodium sulfite; In ethanol; water; Reflux;

With hydrogenchloride; In water; pH=1;

Reference yield:

: (3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7,8-dimethoxy-5-phenyl-1-4-benzothiazepine-1,1-dioxide

: 1345982-59-3
3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-1-propanesulfonic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; aluminum (III) chloride / 1,2-dichloro-ethane / 2.5 h / 20 °C

1.2: Cooling with ice

2.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 120 °C / sealed tube

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

5.2: pH 1 - 2

6.1: borane-THF / tetrahydrofuran / 20 °C

6.2: 0.5 h

7.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C

8.1: sodium sulfite / ethanol; water / Reflux

8.2: pH 1

With pyridine; hydrogenchloride; aluminum (III) chloride; borane-THF; carbon tetrabromide; water; hydrogen; triethylamine; triphenylphosphine; lithium hydroxide; sodium sulfite; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: (3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-5-phenyl-1,4-benzothiazepine-8-ol 1,1-dioxide

: 1345982-59-3
3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-1-propanesulfonic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 120 °C / sealed tube

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

4.2: pH 1 - 2

5.1: borane-THF / tetrahydrofuran / 20 °C

5.2: 0.5 h

6.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C

7.1: sodium sulfite / ethanol; water / Reflux

7.2: pH 1

With pyridine; borane-THF; carbon tetrabromide; water; hydrogen; triethylamine; triphenylphosphine; lithium hydroxide; sodium sulfite; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;