methyl 1-(4'-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,6-difluorobiphenyl-4-yl)cyclopropanecarboxylate

Base Information

Chemical Name:methyl 1-(4'-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,6-difluorobiphenyl-4-yl)cyclopropanecarboxylate
CAS No.:1259023-45-4
Molecular Formula:C₂₄H₂₁F₂N₃O₃
Molecular Weight:437.446
Hs Code.:

Synonyms:methyl 1-(4'-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,6-difluorobiphenyl-4-yl)cyclopropanecarboxylate

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Chemical Property of methyl 1-(4'-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,6-difluorobiphenyl-4-yl)cyclopropanecarboxylate

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Technology Process of methyl 1-(4'-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,6-difluorobiphenyl-4-yl)cyclopropanecarboxylate

There total 1 articles about methyl 1-(4'-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,6-difluorobiphenyl-4-yl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.9%

: 1259022-66-6
4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenylboronic acid

: 1259023-47-6
methyl 1-(3,5-difluoro-4-(trifluoromethylsulfonyloxy)phenyl)cyclopropanecarboxylate

: 1259023-45-4
methyl 1-(4'-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,6-difluorobiphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: With potassium phosphate; lithium chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In propyl cyanide; at 150 ℃; for 1h; Microwave irradiation;

Reference yield: 37.8%

: 1259023-45-4
methyl 1-(4'-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,6-difluorobiphenyl-4-yl)cyclopropanecarboxylate

: 1259022-36-0
1-(4'-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,6-difluorobiphenyl-4-yl)cyclopropanecarboxylic acid

Guidance literature:: methyl 1-(4'-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,6-difluorobiphenyl-4-yl)cyclopropanecarboxylate; With potassium hydroxide; In tert-butyl alcohol; at 40 ℃; for 1h;

With acetic acid; In ethanol; tert-butyl alcohol; for 0.166667h;