diethyl N-<4--N-(3-bromopropyl)amino>benzoyl>-L-glutamate

Base Information

• Chemical Name: diethyl N-<4--N-(3-bromopropyl)amino>benzoyl>-L-glutamate
• CAS No.: 97280-33-6
• Molecular Formula: C₂₈H₃₄BrN₅O₆
• Molecular Weight: 616.512

Synonyms:diethyl N-<4--N-(3-bromopropyl)amino>benzoyl>-L-glutamate

Chemical Property of diethyl N-<4--N-(3-bromopropyl)amino>benzoyl>-L-glutamate

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Technology Process of diethyl N-<4--N-(3-bromopropyl)amino>benzoyl>-L-glutamate

There total 2 articles about diethyl N-<4--N-(3-bromopropyl)amino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide (77766-62-2) + diethyl N-<4-<(3-bromopropyl)amino>benzoyl>-L-glutamate (97280-25-6) → diethyl N-<4--N-(3-bromopropyl)amino>benzoyl>-L-glutamate (97280-33-6)

Guidance literature:

With calcium carbonate; In N,N-dimethyl acetamide; at 25 ℃; for 66h;

DOI:10.1021/jm00148a016

Reference yield:

diethyl N-(p-aminobenzoyl)-L-glutamate (13726-52-8) → diethyl N-<4--N-(3-bromopropyl)amino>benzoyl>-L-glutamate (97280-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 16.5 percent / 2,6-lutidine / N,N-dimethyl-acetamide / 12 h / 100 °C

2: 65 percent / CaCO₃ / N,N-dimethyl-acetamide / 66 h / 25 °C

With 2,6-dimethylpyridine; calcium carbonate; In N,N-dimethyl acetamide;

DOI:10.1021/jm00148a016

Reference yield: 88.0%

sodium cyanide (143-33-9,25596-52-5) + diethyl N-<4--N-(3-bromopropyl)amino>benzoyl>-L-glutamate (97280-33-6) → diethyl N-<4--N-(3-cyanopropyl)amino>benzoyl>-L-glutamate (97280-31-4)

Guidance literature:

In dimethyl sulfoxide; for 4h; Ambient temperature;

DOI:10.1021/jm00148a016

upstream raw materials:

2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide

diethyl N-<4-<(3-bromopropyl)amino>benzoyl>-L-glutamate

diethyl N-(p-aminobenzoyl)-L-glutamate

Downstream raw materials:

diethyl N-<4--N-(3-cyanopropyl)amino>benzoyl>-L-glutamate

(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(3-cyano-propyl)-amino]-benzoylamino}-pentanedioic acid

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