Technology Process of 5-(2,4-dihydroxy-5-isopropyl-benzoyl)-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid cyclopentylamide
There total 8 articles about 5-(2,4-dihydroxy-5-isopropyl-benzoyl)-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid cyclopentylamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium hydroxide monohydrate / water; tetrahydrofuran
2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 6 h / 20 °C
3: boron trichloride / dichloromethane / 0.5 h / -78 °C
With
lithium hydroxide monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; boron trichloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.ejmech.2014.01.056
- Guidance literature:
-
Multi-step reaction with 8 steps
1: toluene-4-sulfonic acid / toluene / Reflux
2: triethylamine / dichloromethane
3: trifluoroacetic acid / dichloromethane / Reflux
4: hydrogenchloride / water / Reflux
5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C
6: lithium hydroxide monohydrate / water; tetrahydrofuran
7: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 6 h / 20 °C
8: boron trichloride / dichloromethane / 0.5 h / -78 °C
With
hydrogenchloride; lithium hydroxide monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; boron trichloride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2014.01.056
