(S)-methyl 3-(3-hydroxypyrrolidin-1-yl)-2-phenylquinoxaline-6-carboxylate

Base Information

Chemical Name:(S)-methyl 3-(3-hydroxypyrrolidin-1-yl)-2-phenylquinoxaline-6-carboxylate
CAS No.:1268866-30-3
Molecular Formula:C₂₀H₁₉N₃O₃
Molecular Weight:349.389
Hs Code.:

Synonyms:(S)-methyl 3-(3-hydroxypyrrolidin-1-yl)-2-phenylquinoxaline-6-carboxylate

Suppliers and Price of (S)-methyl 3-(3-hydroxypyrrolidin-1-yl)-2-phenylquinoxaline-6-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 3-(3-hydroxypyrrolidin-1-yl)-2-phenylquinoxaline-6-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (S)-methyl 3-(3-hydroxypyrrolidin-1-yl)-2-phenylquinoxaline-6-carboxylate

There total 6 articles about (S)-methyl 3-(3-hydroxypyrrolidin-1-yl)-2-phenylquinoxaline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268865-09-3
methyl 3-bromo-2-phenylquinoxaline-6-carboxylate

: 122536-94-1,111810-68-5
(S)-3-hydroxypyrrolidine hydrochloride

: 1268866-30-3
(S)-methyl 3-(3-hydroxypyrrolidin-1-yl)-2-phenylquinoxaline-6-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; toluene; at 100 ℃; for 7h; Sealed tube;

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1268866-30-3
(S)-methyl 3-(3-hydroxypyrrolidin-1-yl)-2-phenylquinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 °C

2.1: ammonium chloride; iron / water; methanol / 5 h / Reflux

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 20 °C

4.1: phosphorus(V) oxybromide / acetonitrile / Reflux

4.2: pH 7 - 8

5.1: N-ethyl-N,N-diisopropylamine / toluene; dimethyl sulfoxide / 7 h / 100 °C / Sealed tube

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; phosphorus(V) oxybromide; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1268866-30-3
(S)-methyl 3-(3-hydroxypyrrolidin-1-yl)-2-phenylquinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 3 h / 0 °C / Reflux

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 °C

3.1: ammonium chloride; iron / water; methanol / 5 h / Reflux

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 20 °C

5.1: phosphorus(V) oxybromide / acetonitrile / Reflux

5.2: pH 7 - 8

6.1: N-ethyl-N,N-diisopropylamine / toluene; dimethyl sulfoxide / 7 h / 100 °C / Sealed tube

With thionyl chloride; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; phosphorus(V) oxybromide; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;