N-(4-benzoyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-5-chloropentanamide

Base Information

Chemical Name:N-(4-benzoyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-5-chloropentanamide
CAS No.:1438407-73-8
Molecular Formula:C₂₀H₂₁ClN₂O₂S
Molecular Weight:388.918
Hs Code.:

Synonyms:N-(4-benzoyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-5-chloropentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-benzoyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-5-chloropentanamide

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Technology Process of N-(4-benzoyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-5-chloropentanamide

There total 5 articles about N-(4-benzoyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-5-chloropentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.73%

: 1575-61-7
5-Chlorovaleroyl chloride

: 1178787-97-7
(6-amino-2H-benzo[b][1,4]thiazin-4(3H)-yl)(phenyl)methanone

: 1438407-73-8
N-(4-benzoyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-5-chloropentanamide

Guidance literature:: (6-amino-2H-benzo[b][1,4]thiazin-4(3H)-yl)(phenyl)methanone; With bis(isopropyl)ethylamine; In tetrahydrofuran; at 0 - 5 ℃; Inert atmosphere;

5-Chlorovaleroyl chloride; In tetrahydrofuran; at 25 ℃; for 2h;

Reference yield:

: 1438407-67-0
2-(2-fluoro-4-nitrophenylthio) ethanamine

: 1438407-73-8
N-(4-benzoyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-5-chloropentanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

2.1: tetrahydrofuran / 5 °C

2.2: 20 - 25 °C

3.1: methanol / 0 - 5 °C

3.2: 65 - 70 °C

4.1: bis(isopropyl)ethylamine / tetrahydrofuran / 0 - 5 °C / Inert atmosphere

4.2: 2 h / 25 °C

With bis(isopropyl)ethylamine; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1438407-73-8
N-(4-benzoyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-5-chloropentanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / water; isopropyl alcohol / 0 - 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

3.1: tetrahydrofuran / 5 °C

3.2: 20 - 25 °C

4.1: methanol / 0 - 5 °C

4.2: 65 - 70 °C

5.1: bis(isopropyl)ethylamine / tetrahydrofuran / 0 - 5 °C / Inert atmosphere

5.2: 2 h / 25 °C

With bis(isopropyl)ethylamine; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;