Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-

Base Information

• Chemical Name: Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-
• CAS No.: 307307-97-7
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 29339980
• Mol file: 307307-97-7.mol

Synonyms:Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-;4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine-3-carboxylic acid;4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylic acid(SALTDATA: FREE);4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxylic acid

Chemical Property of Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-

Chemical Property:

• Boiling Point: 376.713 °C at 760 mmHg
• PKA: 3.89±0.20(Predicted)
• Flash Point: 181.63 °C
• PSA: 55.12000
• Density: 1.454g/cm³
• LogP: 0.91760

Purity/Quality:

97% ^*data from raw suppliers

4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-

There total 3 articles about Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4,5,6,7-Tetrahydropyrazolo<1,5-a>pyridin-3-carbonsaeureethylester (118055-06-4) → 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylic acid (307307-97-7)

Guidance literature:

With water; sodium hydroxide; at 0 - 20 ℃; for 3.5h;

Reference yield:

4,5,6,7-tetrahydro<1.2.3>oxadiazolo<3,4-a>pyridin-3-one (105786-95-6) → 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylic acid (307307-97-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 5,5-dimethyl-1,3-cyclohexadiene / Reflux

2: ethanol; sodium hydroxide

With ethanol; sodium hydroxide; In 5,5-dimethyl-1,3-cyclohexadiene;

DOI:10.1016/j.bmcl.2012.01.080

Reference yield:

pipecolic Acid (4043-87-2,83680-83-5) → 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylic acid (307307-97-7)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic anhydride

2: 5,5-dimethyl-1,3-cyclohexadiene / Reflux

3: ethanol; sodium hydroxide

With ethanol; trifluoroacetic anhydride; sodium hydroxide; In 5,5-dimethyl-1,3-cyclohexadiene;

DOI:10.1016/j.bmcl.2012.01.080

upstream raw materials:

4,5,6,7-tetrahydro<1.2.3>oxadiazolo<3,4-a>pyridin-3-one

4,5,6,7-Tetrahydropyrazolo<1,5-a>pyridin-3-carbonsaeureethylester

pipecolic Acid

Downstream raw materials:

C₂₀H₂₄F₂N₄O

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