methyl (R)-3-[(2S,3R,4R,5R)-3,4-bis(tert-butyldimethylsiloxy)-5-phenyltetrahydrofuran-2-yl]-3-hydroxypropanoate

Base Information

• Chemical Name: methyl (R)-3-[(2S,3R,4R,5R)-3,4-bis(tert-butyldimethylsiloxy)-5-phenyltetrahydrofuran-2-yl]-3-hydroxypropanoate
• CAS No.: 1002753-37-8
• Molecular Formula: C₂₆H₄₆O₆Si₂
• Molecular Weight: 510.819
• Mol file: 1002753-37-8.mol

Synonyms:methyl (R)-3-[(2S,3R,4R,5R)-3,4-bis(tert-butyldimethylsiloxy)-5-phenyltetrahydrofuran-2-yl]-3-hydroxypropanoate

Chemical Property of methyl (R)-3-[(2S,3R,4R,5R)-3,4-bis(tert-butyldimethylsiloxy)-5-phenyltetrahydrofuran-2-yl]-3-hydroxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl (R)-3-[(2S,3R,4R,5R)-3,4-bis(tert-butyldimethylsiloxy)-5-phenyltetrahydrofuran-2-yl]-3-hydroxypropanoate

There total 1 articles about methyl (R)-3-[(2S,3R,4R,5R)-3,4-bis(tert-butyldimethylsiloxy)-5-phenyltetrahydrofuran-2-yl]-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C26H44O6Si2 (1002753-41-4) → methyl (R)-3-[(2S,3R,4R,5R)-3,4-bis(tert-butyldimethylsiloxy)-5-phenyltetrahydrofuran-2-yl]-3-hydroxypropanoate (1002753-37-8)

Guidance literature:

With borane; In tetrahydrofuran; toluene; at 20 ℃; for 2h;

DOI:10.1055/s-2007-990862

Reference yield: 82.0%

methyl (R)-3-[(2S,3R,4R,5R)-3,4-bis(tert-butyldimethylsiloxy)-5-phenyltetrahydrofuran-2-yl]-3-hydroxypropanoate (1002753-37-8) → (2R,3R,3aS,7R,7aS)-3,7-dihydroxy-2-phenyltetrahydro-2H-furo[3,2-b]pyran-5(6H)-one (139626-38-3)

Guidance literature:

With tris(dimethylamino) sulfonium difluorodimethylsilicate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1055/s-2007-990862

upstream raw materials:

C₂₆H₄₄O₆Si₂

Downstream raw materials:

(2R,3R,3aS,7R,7aS)-3,7-dihydroxy-2-phenyltetrahydro-2H-furo[3,2-b]pyran-5(6H)-one