2-chloro-6-(trifluoromethyl)pyrimidine-4-carboxylic Acid

Base Information

Chemical Name:2-chloro-6-(trifluoromethyl)pyrimidine-4-carboxylic Acid
CAS No.:306960-80-5
Molecular Formula:C₆H₂ClF₃N₂O₂
Molecular Weight:226.542
Hs Code.:2933599090
European Community (EC) Number:839-359-0
Mol file:306960-80-5.mol

Synonyms:306960-80-5;2-chloro-6-(trifluoromethyl)pyrimidine-4-carboxylic Acid;657-53-4;2-chloro-4-trifluoromethylpyrimidine-6-carboxylic acid;2-Chloro-6-(trifluoromethyl)-4-pyrimidinecarboxylic acid;4-Pyrimidinecarboxylic acid, 2-chloro-6-(trifluoromethyl)-;2-Chloro-6-pentafluoroethyl-pyrimidine-4-carboxylicacid;NRCWKOWKCBXOBR-UHFFFAOYSA-N;2-CHLORO-6-TRIFLUOROMETHYL-PYRIMIDINE-4-CARBOXYLIC ACID;AKOS016005828;AB60808;SB60236;CS-0239425;EN300-212417;2-Chloro-6-trifluoromethyl-pyrimidine-4-carboxylicacid;Z1269168549;2-Hydroxy-6-(trifluoromethyl)-4-pyrimidinecarboxylic acid

Suppliers and Price of 2-chloro-6-(trifluoromethyl)pyrimidine-4-carboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloro-6-(trifluoromethyl)-4-pyrimidinecarboxylicAcid
25mg
$ 95.00

American Custom Chemicals Corporation
2-CHLORO-6-PENTAFLUOROETHYL-PYRIMIDINE-4-CARBOXYLIC ACID 95.00%
5MG
$ 503.50

Total 8 raw suppliers

Chemical Property of 2-chloro-6-(trifluoromethyl)pyrimidine-4-carboxylic Acid

Chemical Property:

Boiling Point:375.2±42.0 °C(Predicted)
PKA:2.01±0.10(Predicted)
PSA：63.08000
Density:1.692±0.06 g/cm3(Predicted)
LogP:1.84700
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:225.9756895
Heavy Atom Count:14
Complexity:236

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-6-(trifluoromethyl)-4-pyrimidinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(N=C(N=C1C(F)(F)F)Cl)C(=O)O

Technology Process of 2-chloro-6-(trifluoromethyl)pyrimidine-4-carboxylic Acid

There total 2 articles about 2-chloro-6-(trifluoromethyl)pyrimidine-4-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027059-34-2
2-chloro-6-trifluoromethyl-pyrimidine-4-carboxylic acid ethyl ester

: 306960-80-5
2-chloro-4-trifluoromethylpyrimidine-6-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran;
DOI:10.1021/jm0001626

Reference yield:

: ethyl 2-hydroxy-4-trifluoromethylpyrimidine-6-carboxylate

: 306960-80-5
2-chloro-4-trifluoromethylpyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃

2: aq. LiOH / tetrahydrofuran

With lithium hydroxide; trichlorophosphate; In tetrahydrofuran; 1: Chlorination / 2: Hydrolysis;
DOI:10.1021/jm0001626

Reference yield:

: 306960-80-5
2-chloro-4-trifluoromethylpyrimidine-6-carboxylic acid

: 2-chloro-6-trifluoromethyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2 / CH₂Cl₂ / 0.5 h / 20 °C

2: Amberlyst A-21 / ethyl acetate / 1 h / 20 °C

With oxalyl dichloride; Amberlyst A-21; In dichloromethane; ethyl acetate; 1: Chlorination / 2: Acylation;
DOI:10.1021/jm0001626