3-{[5-bromo-2-hydroxy-4-(trifluoromethyl)pyridin-3-yl]oxy}-5-chlorobenzonitrile

Base Information

Chemical Name:3-{[5-bromo-2-hydroxy-4-(trifluoromethyl)pyridin-3-yl]oxy}-5-chlorobenzonitrile
CAS No.:1338226-19-9
Molecular Formula:C₁₃H₅BrClF₃N₂O₂
Molecular Weight:393.547
Hs Code.:

Synonyms:3-{[5-bromo-2-hydroxy-4-(trifluoromethyl)pyridin-3-yl]oxy}-5-chlorobenzonitrile

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Chemical Property of 3-{[5-bromo-2-hydroxy-4-(trifluoromethyl)pyridin-3-yl]oxy}-5-chlorobenzonitrile

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Technology Process of 3-{[5-bromo-2-hydroxy-4-(trifluoromethyl)pyridin-3-yl]oxy}-5-chlorobenzonitrile

There total 9 articles about 3-{[5-bromo-2-hydroxy-4-(trifluoromethyl)pyridin-3-yl]oxy}-5-chlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1155846-86-8
3-chloro-5-{[2-hydroxy-4-(trifluoromethyl)pyridin-3-yl]oxy}benzonitrile

: 1338226-19-9
3-{[5-bromo-2-hydroxy-4-(trifluoromethyl)pyridin-3-yl]oxy}-5-chlorobenzonitrile

Guidance literature:: With N-Bromosuccinimide; In acetonitrile; at 20 ℃;

Reference yield:

: 625-99-0
3-iodochlorobenzene

: 1338226-19-9
3-{[5-bromo-2-hydroxy-4-(trifluoromethyl)pyridin-3-yl]oxy}-5-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4,4'-di-tert-butyl-2,2'-bipyridine; bis(pinacol)diborane / (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / hexanes / 20 °C / Inert atmosphere

1.2: 0.17 h

2.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 20 - 60 °C

3.1: potassium hydroxide / tert-butyl alcohol / 1 h / 75 °C

3.2: 0 °C / pH 5

4.1: N,N-dimethyl-formamide / 17 h / 120 °C / Inert atmosphere

5.1: N-Bromosuccinimide / acetonitrile / 20 °C

With N-Bromosuccinimide; potassium carbonate; bis(pinacol)diborane; 4,4'-di-tert-butyl-2,2'-bipyridine; potassium hydroxide; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In 1-methyl-pyrrolidin-2-one; hexanes; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 628692-22-8
2-chloro-3-fluoro-4-(trifluoromethyl)pyridine

: 1338226-19-9
3-{[5-bromo-2-hydroxy-4-(trifluoromethyl)pyridin-3-yl]oxy}-5-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 120 °C

2: potassium hydroxide / tert-butyl alcohol / 75 °C

3: 1-methyl-pyrrolidin-2-one / 5 h / 175 °C

4: N-Bromosuccinimide / acetonitrile / 20 °C

With N-Bromosuccinimide; potassium carbonate; potassium hydroxide; In 1-methyl-pyrrolidin-2-one; acetonitrile; tert-butyl alcohol;