4-{hydroxy-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-methyl}-1-(toluene-4-sulfonyl)-1H-indol-5-ol

Base Information

Chemical Name:4-{hydroxy-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-methyl}-1-(toluene-4-sulfonyl)-1H-indol-5-ol
CAS No.:1279707-71-9
Molecular Formula:C₃₂H₂₈N₂O₇S₂
Molecular Weight:616.716
Hs Code.:

Synonyms:4-{hydroxy-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-methyl}-1-(toluene-4-sulfonyl)-1H-indol-5-ol

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Chemical Property of 4-{hydroxy-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-methyl}-1-(toluene-4-sulfonyl)-1H-indol-5-ol

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Technology Process of 4-{hydroxy-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-methyl}-1-(toluene-4-sulfonyl)-1H-indol-5-ol

There total 8 articles about 4-{hydroxy-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-methyl}-1-(toluene-4-sulfonyl)-1H-indol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₈H₃₁BN₂O₇S₂

: 1279707-71-9
4-{hydroxy-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-methyl}-1-(toluene-4-sulfonyl)-1H-indol-5-ol

Guidance literature:: With water; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1016/j.tet.2011.01.029

Reference yield:

: 1953-54-4
indol-5-ol

: 1279707-71-9
4-{hydroxy-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-methyl}-1-(toluene-4-sulfonyl)-1H-indol-5-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux

3.2: 20 °C

4.1: propionic acid / toluene / 24 h / Reflux

5.1: water; dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C

With 1H-imidazole; hydrogenchloride; water; dihydrogen peroxide; sodium hydride; propionic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.tet.2011.01.029

Reference yield:

: 106792-38-5
5-(tert-butyl-dimethyl-silanyloxy)-1H-indole

: 1279707-71-9
4-{hydroxy-[5-methoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-methyl}-1-(toluene-4-sulfonyl)-1H-indol-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux

2.2: 20 °C

3.1: propionic acid / toluene / 24 h / Reflux

4.1: water; dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C

With hydrogenchloride; water; dihydrogen peroxide; sodium hydride; propionic acid; In tetrahydrofuran; water; toluene; mineral oil;
DOI:10.1016/j.tet.2011.01.029