O-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyl)-hydroxylamine

Base Information

• Chemical Name: O-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyl)-hydroxylamine
• CAS No.: 679393-85-2
• Molecular Formula: C₁₆H₁₉F₅N₂O
• Molecular Weight: 350.332
• Mol file: 679393-85-2.mol

Synonyms:O-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyl)-hydroxylamine

Chemical Property of O-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyl)-hydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyl)-hydroxylamine

There total 2 articles about O-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyl)-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyloxy)-isoindole-1,3-dione (679393-83-0) → O-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyl)-hydroxylamine (679393-85-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 40h;

DOI:10.1016/j.farmac.2003.08.002

Reference yield:

8-(pentafluoroaniline)-3,7-dimethyl-2,6-octadien-1-ol (447454-19-5) → O-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyl)-hydroxylamine (679393-85-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / PPh₃; diethylazodicarboxylate / tetrahydrofuran / 24 h / 20 °C

2: 89 percent / hydrazine monohydrate / ethanol / 40 h / 20 °C

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; 1: Mitsunobu reaction;

DOI:10.1016/j.farmac.2003.08.002

Reference yield: 45.0%

2-(diethylphosphono)butyric acid + O-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyl)-hydroxylamine (679393-85-2) → [1-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyloxycarbamoyl)-propyl]-phosphonic acid diethyl ester (679393-91-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1016/j.farmac.2003.08.002

upstream raw materials:

2-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyloxy)-isoindole-1,3-dione

8-(pentafluoroaniline)-3,7-dimethyl-2,6-octadien-1-ol

Downstream raw materials:

[((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyloxycarbamoyl)-methyl]-phosphonic acid diethyl ester

[1-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyloxycarbamoyl)-propyl]-phosphonic acid diethyl ester

[((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyloxycarbamoyl)-methyl]-phosphonic acid

[1-((2E,6E)-3,7-Dimethyl-8-pentafluorophenylamino-octa-2,6-dienyloxycarbamoyl)-propyl]-phosphonic acid