C₂₀H₂₇N₃O₆

Base Information

• Chemical Name: C₂₀H₂₇N₃O₆
• CAS No.: 1146538-44-4
• Molecular Formula: C₂₀H₂₇N₃O₆
• Molecular Weight: 405.451
• Mol file: 1146538-44-4.mol

Synonyms:C₂₀H₂₇N₃O₆

Chemical Property of C₂₀H₂₇N₃O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₇N₃O₆

There total 4 articles about C₂₀H₂₇N₃O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

Z-Lys(Boc)-OH (2389-60-8) + 3-oxo-1λ3-benzo[d][1,2]iodaoxole-1(3H)-carbonitrile (172876-96-9) → C20H27N3O6 (1146538-44-4)

Guidance literature:

With dmap; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b03843

Reference yield: 77.0%

N-((1S)-1-(4-[(tert-butoxy)carbonylamino]butyl)-2-carbamoyl-2-hydroxyethyl)(phenylmethoxy)-carboxamide (1146538-36-4) → C20H27N3O6 (1146538-44-4)

Guidance literature:

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In dichloromethane; water; Inert atmosphere;

DOI:10.1016/j.tet.2009.01.078

Reference yield:

1-acetoxy-1,2-benziodoxol-3-one (1829-26-1) → C20H27N3O6 (1146538-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: dmap / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With dmap; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acs.orglett.8b03843

upstream raw materials:

N-((1S)-1-(4-[(tert-butoxy)carbonylamino]butyl)-2-carbamoyl-2-hydroxyethyl)(phenylmethoxy)-carboxamide

1-hydroxy-1,2-benzodioxol-3-(1H)-one

1-acetoxy-1,2-benziodoxol-3-one

Z-Lys(Boc)-OH