C₂₇H₂₈N₂O₉

Base Information

• Chemical Name: C₂₇H₂₈N₂O₉
• CAS No.: 1315454-89-7
• Molecular Formula: C₂₇H₂₈N₂O₉
• Molecular Weight: 524.527
• Mol file: 1315454-89-7.mol

Synonyms:C₂₇H₂₈N₂O₉

Chemical Property of C₂₇H₂₈N₂O₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₈N₂O₉

There total 28 articles about C₂₇H₂₈N₂O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

C29H30N2O10 (1315454-86-4) → C27H28N2O9 (1315454-89-7) + C27H28N2O9 (1315454-87-5)

Guidance literature:

With methanol; sodium methylate; In tetrahydrofuran; at 78 ℃; Inert atmosphere;

DOI:10.1002/chem.201003489

Reference yield: 52.0%

C27H28N2O8 (1315454-85-3) → C27H28N2O9 (1315454-89-7)

Guidance literature:

C₂₇H₂₈N₂O₈; With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

With acetic anhydride; In tetrahydrofuran; at -15 ℃; for 34h; Inert atmosphere;

DOI:10.1002/chem.201003489

Reference yield:

3-Benzyloxy-4-iodo-5-nitro-benzoic acid methyl ester (163495-25-8) → C27H28N2O9 (1315454-89-7)

Guidance literature:

Multi-step reaction with 11 steps

1: iron; acetic acid / tetrahydrofuran; methanol / 3.5 h / 20 °C / Inert atmosphere

2: acetic acid / chloroform / 12 h / 20 °C / Molecular sieve; Inert atmosphere

3: sodium cyanoborohydride / tetrahydrofuran / 2 h / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

5: dmap; potassium carbonate / dichloromethane / 20 °C / Inert atmosphere

6: 1,4-diaza-bicyclo[2.2.2]octane; bis(1,5-cyclooctadiene)diiridium(I) dichloride; (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-(1-phenyl-ethyl)-amine / tetrahydrofuran / 20 °C / Inert atmosphere

7: palladium diacetate; silver nitrate; triphenylphosphine / 1,4-dioxane / 1 h / 80 °C / Inert atmosphere

8: 4-methyl-morpholine; osmium(VIII) oxide / tetrahydrofuran; water; acetone / 3 h / 20 °C / Inert atmosphere

9: pyridine / dichloromethane / 0.08 h / -78 - 0 °C / Inert atmosphere

10: tetrahydrofuran / 24 h / -20 - 0 °C / Inert atmosphere

11: methanol; sodium methylate / tetrahydrofuran / 78 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; 1,4-diaza-bicyclo[2.2.2]octane; methanol; dmap; osmium(VIII) oxide; bis(1,5-cyclooctadiene)diiridium(I) dichloride; tetrabutyl ammonium fluoride; sodium methylate; palladium diacetate; iron; sodium cyanoborohydride; potassium carbonate; silver nitrate; acetic acid; triphenylphosphine; (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-(1-phenyl-ethyl)-amine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; acetone; 9: Polonovski reaction;

DOI:10.1002/chem.201003489

upstream raw materials:

(3S,4S)-4-N-phthalimido-1,5-hexadiene-3-ol

3-benzyloxy-4-iodo-5-nitrobenzaldehyde

methyl 3-amino-5-benzyloxy-4-iodobenzoate

C₂₀H₂₇NO₃Si

Downstream raw materials:

C₂₇H₂₈N₂O₁₀

C₂₇H₂₈N₂O₁₀