Morpholin-4-yl-phosphonic acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,4-dichloro-phenyl ester

Base Information

• Chemical Name: Morpholin-4-yl-phosphonic acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,4-dichloro-phenyl ester
• CAS No.: 80973-40-6
• Molecular Formula: C₂₆H₃₈Cl₂N₃O₈PSi
• Molecular Weight: 650.568
• Mol file: 80973-40-6.mol

Synonyms:Morpholin-4-yl-phosphonic acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,4-dichloro-phenyl ester

Chemical Property of Morpholin-4-yl-phosphonic acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,4-dichloro-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Morpholin-4-yl-phosphonic acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,4-dichloro-phenyl ester

There total 3 articles about Morpholin-4-yl-phosphonic acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,4-dichloro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,4-dichloro-phenyl ester (80973-42-8) → Morpholin-4-yl-phosphonic acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,4-dichloro-phenyl ester (80973-40-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1246/cl.1981.1725

Reference yield:

Phosphoric acid dibenzotriazol-1-yl ester 2,4-dichloro-phenyl ester (82410-50-2) → Morpholin-4-yl-phosphonic acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,4-dichloro-phenyl ester (80973-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran

2: 90 percent / tetrahydrofuran / 0.5 h / 20 °C

In tetrahydrofuran;

DOI:10.1246/cl.1981.1725

Reference yield:

5'-tert-butyldimethylsilyloxy-2'-deoxythymidine (40733-28-6) → Morpholin-4-yl-phosphonic acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,4-dichloro-phenyl ester (80973-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran

2: 90 percent / tetrahydrofuran / 0.5 h / 20 °C

In tetrahydrofuran;

DOI:10.1246/cl.1981.1725

upstream raw materials:

morpholine

Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,4-dichloro-phenyl ester

Phosphoric acid dibenzotriazol-1-yl ester 2,4-dichloro-phenyl ester

5'-tert-butyldimethylsilyloxy-2'-deoxythymidine