3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-{4-[(1R,2S)-1-(2-furyl)-2,3-dihydroxypropyl]piperazin-1-yl}butyl]-N-methyl-1-naphthamide

Base Information

Chemical Name:3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-{4-[(1R,2S)-1-(2-furyl)-2,3-dihydroxypropyl]piperazin-1-yl}butyl]-N-methyl-1-naphthamide
CAS No.:939972-38-0
Molecular Formula:C₃₄H₃₆Cl₂N₄O₄
Molecular Weight:635.59
Hs Code.:

Synonyms:3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-{4-[(1R,2S)-1-(2-furyl)-2,3-dihydroxypropyl]piperazin-1-yl}butyl]-N-methyl-1-naphthamide

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Chemical Property of 3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-{4-[(1R,2S)-1-(2-furyl)-2,3-dihydroxypropyl]piperazin-1-yl}butyl]-N-methyl-1-naphthamide

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Technology Process of 3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-{4-[(1R,2S)-1-(2-furyl)-2,3-dihydroxypropyl]piperazin-1-yl}butyl]-N-methyl-1-naphthamide

There total 9 articles about 3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-{4-[(1R,2S)-1-(2-furyl)-2,3-dihydroxypropyl]piperazin-1-yl}butyl]-N-methyl-1-naphthamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 255050-48-7
3-cyano-naphthalene-1-carbonyl chloride

: 939972-38-0
3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-{4-[(1R,2S)-1-(2-furyl)-2,3-dihydroxypropyl]piperazin-1-yl}butyl]-N-methyl-1-naphthamide

Guidance literature:: C₂₇H₃₉Cl₂N₃O₅; With hydrogenchloride; water; isopropyl alcohol; In dichloromethane; tert-butyl methyl ether; at 20 - 30 ℃; for 16h;

3-cyano-naphthalene-1-carbonyl chloride; With potassium hydroxide; In tetrahydrofuran; dichloromethane; water; at 20 ℃; for 15h; Product distribution / selectivity;

Reference yield:

: 255050-50-1
N-[2-(S)-(3,4-dichlorophenyl)-4-oxobutyl]-N-methyl-3-cyano-1-naphthamide

: (1R,2S)-1-furan-2-yl-1-piperazin-1-yl-butan-2-ol dihydrochloride

: 939972-38-0
3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-{4-[(1R,2S)-1-(2-furyl)-2,3-dihydroxypropyl]piperazin-1-yl}butyl]-N-methyl-1-naphthamide

Guidance literature:: N-[2-(S)-(3,4-dichlorophenyl)-4-oxobutyl]-N-methyl-3-cyano-1-naphthamide; (1R,2S)-1-furan-2-yl-1-piperazin-1-yl-butan-2-ol dihydrochloride; With acetic acid; In tetrahydrofuran; water; for 4h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; water; at 20 ℃; for 15h;

With potassium hydroxide; water; In tert-butyl methyl ether; ethyl acetate; Product distribution / selectivity;

Reference yield:

: 3839-18-7
3-cyano-1-naphthoic acid

: 939972-38-0
3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-{4-[(1R,2S)-1-(2-furyl)-2,3-dihydroxypropyl]piperazin-1-yl}butyl]-N-methyl-1-naphthamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 4 h / 30 - 40 °C

2.1: hydrogenchloride; water; isopropyl alcohol / dichloromethane; tert-butyl methyl ether / 16 h / 20 - 30 °C

2.2: 15 h / 20 °C

With hydrogenchloride; oxalyl dichloride; water; isopropyl alcohol; N,N-dimethyl-formamide; In dichloromethane; tert-butyl methyl ether;