(1R)-1-[N-(9-phenylfluoren-9-yl)-D-methionyl]amino-ethylboronate (+)-pinanediol ester

Base Information

• Chemical Name: (1R)-1-[N-(9-phenylfluoren-9-yl)-D-methionyl]amino-ethylboronate (+)-pinanediol ester
• CAS No.: 942216-68-4
• Molecular Formula: C₃₆H₄₃BN₂O₃S
• Molecular Weight: 594.626
• Mol file: 942216-68-4.mol

Synonyms:(1R)-1-[N-(9-phenylfluoren-9-yl)-D-methionyl]amino-ethylboronate (+)-pinanediol ester

Chemical Property of (1R)-1-[N-(9-phenylfluoren-9-yl)-D-methionyl]amino-ethylboronate (+)-pinanediol ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-1-[N-(9-phenylfluoren-9-yl)-D-methionyl]amino-ethylboronate (+)-pinanediol ester

There total 4 articles about (1R)-1-[N-(9-phenylfluoren-9-yl)-D-methionyl]amino-ethylboronate (+)-pinanediol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H31BO3N2S + 9-bromo-9-phenyl-9H-fluorene (55135-66-5) → (1R)-1-[N-(9-phenylfluoren-9-yl)-D-methionyl]amino-ethylboronate (+)-pinanediol ester (942216-68-4)

Guidance literature:

With potassium phosphate; lead(II) nitrate; triethylamine; In acetonitrile; at 20 ℃; for 48h;

DOI:10.1021/jm061321+

Reference yield:

(R)-boroalanine-(1S,2S,3R,5S)-(+)-2,3-pinanediol ester hydrochloride (919103-31-4,858354-78-6) → (1R)-1-[N-(9-phenylfluoren-9-yl)-D-methionyl]amino-ethylboronate (+)-pinanediol ester (942216-68-4)

Guidance literature:

Multi-step reaction with 3 steps

1: DIPEA; HATU / dimethylformamide / 20 °C

2: HCl / dioxane / 3 h / 20 °C

3: Pb(NO₃)2; Et₃N; K₃PO₄ / acetonitrile / 48 h / 20 °C

With hydrogenchloride; potassium phosphate; lead(II) nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm061321+

Reference yield:

(1R)-1-[N-(tert-butoxycarbonyl)-D-methionyl]amino-ethylboronate (+)-pinanediol ester (942216-67-3) → (1R)-1-[N-(9-phenylfluoren-9-yl)-D-methionyl]amino-ethylboronate (+)-pinanediol ester (942216-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / dioxane / 3 h / 20 °C

2: Pb(NO₃)2; Et₃N; K₃PO₄ / acetonitrile / 48 h / 20 °C

With hydrogenchloride; potassium phosphate; lead(II) nitrate; triethylamine; In 1,4-dioxane; acetonitrile;

DOI:10.1021/jm061321+

upstream raw materials:

9-bromo-9-phenyl-9H-fluorene

(R)-boroalanine-(1S,2S,3R,5S)-(+)-2,3-pinanediol ester hydrochloride

(1R)-1-[N-(tert-butoxycarbonyl)-D-methionyl]amino-ethylboronate (+)-pinanediol ester

(R)-N-(tert-butoxycarbonyl)methionine