2-(2-Amino-4-chloro-phenylamino)-1-[(R)-4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-ethanone

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Chemical Name:2-(2-Amino-4-chloro-phenylamino)-1-[(R)-4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-ethanone
CAS No.:871324-86-6
Molecular Formula:C₂₀H₂₄ClFN₄O
Molecular Weight:390.888
Hs Code.:

Synonyms:2-(2-Amino-4-chloro-phenylamino)-1-[(R)-4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-ethanone

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Chemical Property of 2-(2-Amino-4-chloro-phenylamino)-1-[(R)-4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-ethanone

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Technology Process of 2-(2-Amino-4-chloro-phenylamino)-1-[(R)-4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-ethanone

There total 4 articles about 2-(2-Amino-4-chloro-phenylamino)-1-[(R)-4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 871324-84-4
2-(4-Chloro-2-nitro-phenylamino)-1-[(R)-4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-ethanone

: 871324-86-6
2-(2-Amino-4-chloro-phenylamino)-1-[(R)-4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-ethanone

Guidance literature:: With hydrogenchloride; tin(ll) chloride; In ethanol; for 0.25h; Heating;
DOI:10.1016/j.bmcl.2005.08.057

Reference yield:

: 422270-30-2
2-chloro-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone

: 871324-86-6
2-(2-Amino-4-chloro-phenylamino)-1-[(R)-4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / dimethylformamide / 0.5 h / 120 °C

2: 96 percent / H₂NNH₂ / methanol / 1.5 h / Heating

3: 30 percent / 0.75 h / 130 °C

4: 93 percent / SnCl₂; aq. HCl / ethanol / 0.25 h / Heating

With hydrogenchloride; tin(ll) chloride; hydrazine; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.08.057

Reference yield:

: 871324-83-3
2-Amino-1-[(R)-4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-ethanone

: 871324-86-6
2-(2-Amino-4-chloro-phenylamino)-1-[(R)-4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / 0.75 h / 130 °C

2: 93 percent / SnCl₂; aq. HCl / ethanol / 0.25 h / Heating

With hydrogenchloride; tin(ll) chloride; In ethanol;
DOI:10.1016/j.bmcl.2005.08.057