octyl t-(2,7)-bis(3-(4-(trifluoromethyl)phenyl)ureido)-t-8a-decahydronaphthalene-r-4a-carboxylate

Base Information

Chemical Name:octyl t-(2,7)-bis(3-(4-(trifluoromethyl)phenyl)ureido)-t-8a-decahydronaphthalene-r-4a-carboxylate
CAS No.:1266351-53-4
Molecular Formula:C₃₅H₄₄F₆N₄O₄
Molecular Weight:698.749
Hs Code.:

Synonyms:octyl t-(2,7)-bis(3-(4-(trifluoromethyl)phenyl)ureido)-t-8a-decahydronaphthalene-r-4a-carboxylate

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Chemical Property of octyl t-(2,7)-bis(3-(4-(trifluoromethyl)phenyl)ureido)-t-8a-decahydronaphthalene-r-4a-carboxylate

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Technology Process of octyl t-(2,7)-bis(3-(4-(trifluoromethyl)phenyl)ureido)-t-8a-decahydronaphthalene-r-4a-carboxylate

There total 10 articles about octyl t-(2,7)-bis(3-(4-(trifluoromethyl)phenyl)ureido)-t-8a-decahydronaphthalene-r-4a-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 629-27-6
1-Iodooctane

: 1266351-59-0
t-(2,7)-bis(3-(4-(trifluoromethyl)phenyl)ureido)-t-8a-decahydronaphthalene-r-4a-carboxylic acid

: 1266351-53-4
octyl t-(2,7)-bis(3-(4-(trifluoromethyl)phenyl)ureido)-t-8a-decahydronaphthalene-r-4a-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/ja1076102

Reference yield:

: 1266351-42-1
methyl c-(2,7)-bis(methylsulfonyloxy)-t-8a-decahydronaphthalene-r-4a-carboxylate

: 1266351-53-4
octyl t-(2,7)-bis(3-(4-(trifluoromethyl)phenyl)ureido)-t-8a-decahydronaphthalene-r-4a-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium azide / N,N-dimethyl-formamide / 20 h / 100 °C

2.1: acetic acid; zinc / 12 h / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / methanol / 2 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 17 h / 0 - 20 °C

4.2: 2 h / 20 °C

5.1: lithium bromide / N,N-dimethyl-formamide / 72 h / 140 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

With sodium azide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium bromide; zinc; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja1076102

Reference yield:

: 1266351-43-2
methyl t-(2,7)-diazido-t-8a-decahydronaphthalene-r-4a-carboxylate

: 1266351-53-4
octyl t-(2,7)-bis(3-(4-(trifluoromethyl)phenyl)ureido)-t-8a-decahydronaphthalene-r-4a-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; zinc / 12 h / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / methanol / 2 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 17 h / 0 - 20 °C

3.2: 2 h / 20 °C

4.1: lithium bromide / N,N-dimethyl-formamide / 72 h / 140 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

With potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium bromide; zinc; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja1076102