1,4-Dihydro-6-methyl-2-(methylthio)-4-(2-(5-tert-butyldimethylsilyloxypentylthio)phenyl)5-pyrimidinecarboxylic acid, 2-(trimethylsilyl)ethyl ester

Base Information

Chemical Name:1,4-Dihydro-6-methyl-2-(methylthio)-4-(2-(5-tert-butyldimethylsilyloxypentylthio)phenyl)5-pyrimidinecarboxylic acid, 2-(trimethylsilyl)ethyl ester
CAS No.:145457-85-8
Molecular Formula:C₂₉H₅₀N₂O₃S₂Si₂
Molecular Weight:595.031
Hs Code.:

1,4-Dihydro-6-methyl-2-(methylthio)-4-(2-(5-tert-butyldimethylsilyloxypentylthio)phenyl)5-pyrimidinecarboxylic acid, 2-(trimethylsilyl)ethyl ester

Synonyms:1,4-Dihydro-6-methyl-2-(methylthio)-4-(2-(5-tert-butyldimethylsilyloxypentylthio)phenyl)5-pyrimidinecarboxylic acid, 2-(trimethylsilyl)ethyl ester

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Chemical Property of 1,4-Dihydro-6-methyl-2-(methylthio)-4-(2-(5-tert-butyldimethylsilyloxypentylthio)phenyl)5-pyrimidinecarboxylic acid, 2-(trimethylsilyl)ethyl ester

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Technology Process of 1,4-Dihydro-6-methyl-2-(methylthio)-4-(2-(5-tert-butyldimethylsilyloxypentylthio)phenyl)5-pyrimidinecarboxylic acid, 2-(trimethylsilyl)ethyl ester

There total 8 articles about 1,4-Dihydro-6-methyl-2-(methylthio)-4-(2-(5-tert-butyldimethylsilyloxypentylthio)phenyl)5-pyrimidinecarboxylic acid, 2-(trimethylsilyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14527-26-5,867-44-7,147895-43-0
2-methylisothiourea sulphate

: 2-[1-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-phenyl}-meth-(Z)-ylidene]-3-oxo-butyric acid 2-trimethylsilanyl-ethyl ester

: 145457-85-8
1,4-Dihydro-6-methyl-2-(methylthio)-4-(2-(5-tert-butyldimethylsilyloxypentylthio)phenyl)5-pyrimidinecarboxylic acid, 2-(trimethylsilyl)ethyl ester

Guidance literature:: With sodium acetate; In N,N-dimethyl-formamide; at 75 ℃; for 4h;
DOI:10.1021/jm00001a017

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 145457-85-8
1,4-Dihydro-6-methyl-2-(methylthio)-4-(2-(5-tert-butyldimethylsilyloxypentylthio)phenyl)5-pyrimidinecarboxylic acid, 2-(trimethylsilyl)ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate / toluene / 90 °C

2: acetic acid, piperidine / benzene / 1 h / Heating

3: sodium acetate / dimethylformamide / 4 h / 75 °C

With piperidine; sodium acetate; acetic acid; In N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm00001a017

Reference yield:

: 6320-02-1
o-bromothiophenol

: 145457-85-8
1,4-Dihydro-6-methyl-2-(methylthio)-4-(2-(5-tert-butyldimethylsilyloxypentylthio)phenyl)5-pyrimidinecarboxylic acid, 2-(trimethylsilyl)ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: DBU, NaI / acetone / Heating

2: n-butyllithium / tetrahydrofuran / -100 °C

3: acetic acid, piperidine / benzene / 1 h / Heating

4: sodium acetate / dimethylformamide / 4 h / 75 °C

With piperidine; n-butyllithium; sodium acetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jm00001a017