Diethyl-N-<4-(N-methyl)aminobenzoyl>-β-(4-bromphenyl)glutamat

Base Information

• Chemical Name: Diethyl-N-<4-(N-methyl)aminobenzoyl>-β-(4-bromphenyl)glutamat
• CAS No.: 136450-99-2
• Molecular Formula: C₂₃H₂₇BrN₂O₅
• Molecular Weight: 491.382
• Mol file: 136450-99-2.mol

Synonyms:Diethyl-N-<4-(N-methyl)aminobenzoyl>-β-(4-bromphenyl)glutamat

Chemical Property of Diethyl-N-<4-(N-methyl)aminobenzoyl>-β-(4-bromphenyl)glutamat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diethyl-N-<4-(N-methyl)aminobenzoyl>-β-(4-bromphenyl)glutamat

There total 1 articles about Diethyl-N-<4-(N-methyl)aminobenzoyl>-β-(4-bromphenyl)glutamat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-(N-Methyl-N-tosyl)aminobenzoylchlorid (16879-69-9) + Diethyl-3-(4-bromphenyl)glutamat Tosylat (136450-93-6) → Diethyl-N-<4-(N-methyl)aminobenzoyl>-β-(4-bromphenyl)glutamat (136450-99-2)

Guidance literature:

With potassium hydrogencarbonate; In dichloromethane; water; for 12h; Ambient temperature;

DOI:10.1002/ardp.2503240808

Reference yield: 76.0%

6-bromomethyl-pteridine-2,4-diamine (59368-16-0) + Diethyl-N-<4-(N-methyl)aminobenzoyl>-β-(4-bromphenyl)glutamat (136450-99-2) → Diethyl-N-<4-<(2,4-diamino-6-pteridinyl)methyl>-N-methylaminobenzoyl>-β-(4-bromphenyl)glutamat (136451-03-1)

Guidance literature:

In N,N-dimethyl acetamide; 1.) 50 to 55 deg C, 4 h 2.) 25 deg C, 17 h;

DOI:10.1002/ardp.2503240808

Reference yield:

Diethyl-N-<4-(N-methyl)aminobenzoyl>-β-(4-bromphenyl)glutamat (136450-99-2) → N-<4-<(2,4-Diamino-6-pteridinyl)methyl>methylaminobenzoyl>-β-(4-bromphenyl)glutaminsaeure (136451-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / N,N-dimethyl-acetamide / 1.) 50 to 55 deg C, 4 h 2.) 25 deg C, 17 h

2: 92 percent / N aq. NaOH / ethanol / 3 h / Ambient temperature

With sodium hydroxide; In ethanol; N,N-dimethyl acetamide;

DOI:10.1002/ardp.2503240808

upstream raw materials:

4-(N-Methyl-N-tosyl)aminobenzoylchlorid

Diethyl-3-(4-bromphenyl)glutamat Tosylat

Downstream raw materials:

Diethyl-N-<4-<(2,4-diamino-6-pteridinyl)methyl>-N-methylaminobenzoyl>-β-(4-bromphenyl)glutamat

N-<4-<(2,4-Diamino-6-pteridinyl)methyl>methylaminobenzoyl>-β-(4-bromphenyl)glutaminsaeure