ethyl 2-(((5-(N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamoyl)-3-((bis(ethoxycarbonyl)methylamino)methyl)phenyl)methyl)(ethoxycarbonyl)methylamino)acetate

Base Information

Chemical Name:ethyl 2-(((5-(N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamoyl)-3-((bis(ethoxycarbonyl)methylamino)methyl)phenyl)methyl)(ethoxycarbonyl)methylamino)acetate
CAS No.:225115-93-5
Molecular Formula:C₃₁H₅₀N₄O₁₁
Molecular Weight:654.758
Hs Code.:

ethyl 2-(((5-(N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamoyl)-3-((bis(ethoxycarbonyl)methylamino)methyl)phenyl)methyl)(ethoxycarbonyl)methylamino)acetate

Synonyms:ethyl 2-(((5-(N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamoyl)-3-((bis(ethoxycarbonyl)methylamino)methyl)phenyl)methyl)(ethoxycarbonyl)methylamino)acetate

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Chemical Property of ethyl 2-(((5-(N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamoyl)-3-((bis(ethoxycarbonyl)methylamino)methyl)phenyl)methyl)(ethoxycarbonyl)methylamino)acetate

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Technology Process of ethyl 2-(((5-(N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamoyl)-3-((bis(ethoxycarbonyl)methylamino)methyl)phenyl)methyl)(ethoxycarbonyl)methylamino)acetate

There total 5 articles about ethyl 2-(((5-(N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamoyl)-3-((bis(ethoxycarbonyl)methylamino)methyl)phenyl)methyl)(ethoxycarbonyl)methylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 225115-91-3
[(3-[(bis-ethoxycarbonylmethyl-amino)-methyl]-5-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethylcarbamoyl}-benzyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester

: 225115-93-5
ethyl 2-(((5-(N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamoyl)-3-((bis(ethoxycarbonyl)methylamino)methyl)phenyl)methyl)(ethoxycarbonyl)methylamino)acetate

Guidance literature:: With trifluoroacetic acid; for 2.5h; Ambient temperature;
DOI:10.1021/jo982397j

Reference yield:

: 6290-05-7
Diethyl iminodiacetate

: 225115-93-5
ethyl 2-(((5-(N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamoyl)-3-((bis(ethoxycarbonyl)methylamino)methyl)phenyl)methyl)(ethoxycarbonyl)methylamino)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / K₂CO₃ / acetonitrile / Ambient temperature; sonication

2: 91 percent / TFA / 2.5 h / Ambient temperature

3: 90 percent / BOP, Et₃N / acetonitrile / 12 h / Ambient temperature

4: 97 percent / TFA / 2.5 h / Ambient temperature

With potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In acetonitrile;
DOI:10.1021/jo982397j

Reference yield:

: 156597-80-7
3,5-Bis(brommethyl)benzoesaeure-tert-butylester

: 225115-93-5
ethyl 2-(((5-(N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamoyl)-3-((bis(ethoxycarbonyl)methylamino)methyl)phenyl)methyl)(ethoxycarbonyl)methylamino)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / K₂CO₃ / acetonitrile / Ambient temperature; sonication

2: 91 percent / TFA / 2.5 h / Ambient temperature

3: 90 percent / BOP, Et₃N / acetonitrile / 12 h / Ambient temperature

4: 97 percent / TFA / 2.5 h / Ambient temperature

With potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In acetonitrile;
DOI:10.1021/jo982397j