ethyl 4-({(1-bromo-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate

Base Information

• Chemical Name: ethyl 4-({(1-bromo-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate
• CAS No.: 1400702-26-2
• Molecular Formula: C₂₇H₂₂BrF₃N₂O₅S
• Molecular Weight: 623.447
• Mol file: 1400702-26-2.mol

Synonyms:ethyl 4-({(1-bromo-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate

Chemical Property of ethyl 4-({(1-bromo-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 4-({(1-bromo-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate

There total 1 articles about ethyl 4-({(1-bromo-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ ethyl 4-({(1-bromo-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate (1400702-26-2)

Guidance literature:

Reference yield: 99.0%

potassium cyclopropyltrifluoroborate (1065010-87-8) + ethyl 4-({(1-bromo-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate (1400702-26-2) → ethyl 4-({(1-cyclopropyl-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl] amino}sulfonyl)benzoate (1400698-63-6)

Guidance literature:

With caesium carbonate; palladium diacetate; catacxium A; In water; toluene; for 3h; Inert atmosphere; Reflux;

Reference yield: 58.0%

ethyl 4-({(1-bromo-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate (1400702-26-2) + isopropyl alcohol (67-63-0,8013-70-5) → 4-({(1-isopropoxy-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoic acid (1400699-58-2)

Guidance literature:

ethyl 4-({(1-bromo-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate; isopropyl alcohol; With sodium hydride; In tetrahydrofuran; for 4h; Inert atmosphere; Reflux;

With hydrogenchloride; water; In tetrahydrofuran;

Downstream raw materials:

ethyl 4-({(4-methyl-1-pyrrolidin-1-ylisoquinolin-3-yl)[4-(trifluoromethoxy)-benzyl]amino}sulfonyl)benzoate

4-({(1-isopropoxy-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoic acid

ethyl 4-({[1-(1-ethoxyvinyl)-4-methylisoquinolin-3-yl][4-(trifluoromethoxy)benzyl]amino}-sulfonyl)benzoate

ethyl 4-({(1-cyclopropyl-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl] amino}sulfonyl)benzoate