(R)-2-(2-{[(2S,3R)-2-((R)-2-{2-[((2S,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoyl)-methyl-amino]-acetoxy}-3-phenyl-propionylamino)-3-methyl-pentanoyl]-methyl-amino}-acetoxy)-3-phenyl-propionic acid

Base Information

Chemical Name:(R)-2-(2-{[(2S,3R)-2-((R)-2-{2-[((2S,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoyl)-methyl-amino]-acetoxy}-3-phenyl-propionylamino)-3-methyl-pentanoyl]-methyl-amino}-acetoxy)-3-phenyl-propionic acid
CAS No.:858972-98-2
Molecular Formula:C₄₁H₅₈N₄O₁₁
Molecular Weight:782.932
Hs Code.:

(R)-2-(2-{[(2S,3R)-2-((R)-2-{2-[((2S,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoyl)-methyl-amino]-acetoxy}-3-phenyl-propionylamino)-3-methyl-pentanoyl]-methyl-amino}-acetoxy)-3-phenyl-propionic acid

Synonyms:(R)-2-(2-{[(2S,3R)-2-((R)-2-{2-[((2S,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoyl)-methyl-amino]-acetoxy}-3-phenyl-propionylamino)-3-methyl-pentanoyl]-methyl-amino}-acetoxy)-3-phenyl-propionic acid

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Chemical Property of (R)-2-(2-{[(2S,3R)-2-((R)-2-{2-[((2S,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoyl)-methyl-amino]-acetoxy}-3-phenyl-propionylamino)-3-methyl-pentanoyl]-methyl-amino}-acetoxy)-3-phenyl-propionic acid

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Technology Process of (R)-2-(2-{[(2S,3R)-2-((R)-2-{2-[((2S,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoyl)-methyl-amino]-acetoxy}-3-phenyl-propionylamino)-3-methyl-pentanoyl]-methyl-amino}-acetoxy)-3-phenyl-propionic acid

There total 6 articles about (R)-2-(2-{[(2S,3R)-2-((R)-2-{2-[((2S,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoyl)-methyl-amino]-acetoxy}-3-phenyl-propionylamino)-3-methyl-pentanoyl]-methyl-amino}-acetoxy)-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 858972-92-6
2-(2-{[2-(2-{2-[(2-tert-butoxycarbonylamino-3-methylpentanoyl)methylamino]acetoxy}-3-phenyl-propionylamino)-3-methylpentanoyl]methylamino}acetoxy)-3-phenylpropionic acid benzyl ester

: 858972-98-2
(R)-2-(2-{[(2S,3R)-2-((R)-2-{2-[((2S,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoyl)-methyl-amino]-acetoxy}-3-phenyl-propionylamino)-3-methyl-pentanoyl]-methyl-amino}-acetoxy)-3-phenyl-propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2005.04.087

Reference yield:

: (R)-2-{2-[((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoyl)-methyl-amino]-acetoxy}-3-phenyl-propionic acid

: 858972-98-2
(R)-2-(2-{[(2S,3R)-2-((R)-2-{2-[((2S,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoyl)-methyl-amino]-acetoxy}-3-phenyl-propionylamino)-3-methyl-pentanoyl]-methyl-amino}-acetoxy)-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / BOP-Cl; diisopropyl ethylamine; HOBt / CH₂Cl₂ / 24 h / 0 - 20 °C

2: 86 percent / H₂ / Pd/C / ethyl acetate / 24 h / 20 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2005.04.087

Reference yield:

: (R)-2-{2-[((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoyl)-methyl-amino]-acetoxy}-3-phenyl-propionic acid benzyl ester

: 858972-98-2
(R)-2-(2-{[(2S,3R)-2-((R)-2-{2-[((2S,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoyl)-methyl-amino]-acetoxy}-3-phenyl-propionylamino)-3-methyl-pentanoyl]-methyl-amino}-acetoxy)-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethyl acetate / 24 h / 20 °C

2: 77 percent / BOP-Cl; diisopropyl ethylamine; HOBt / CH₂Cl₂ / 24 h / 0 - 20 °C

3: 86 percent / H₂ / Pd/C / ethyl acetate / 24 h / 20 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2005.04.087