(S)-methyl 2-(benzyloxycarbonylamino)-2-(oxetan-3-yl)acetate

Base Information

• Chemical Name: (S)-methyl 2-(benzyloxycarbonylamino)-2-(oxetan-3-yl)acetate
• CAS No.: 1213783-62-0
• Molecular Formula: C₁₄H₁₇NO₅
• Molecular Weight: 279.293
• Mol file: 1213783-62-0.mol

Synonyms:(S)-methyl 2-(benzyloxycarbonylamino)-2-(oxetan-3-yl)acetate

Chemical Property of (S)-methyl 2-(benzyloxycarbonylamino)-2-(oxetan-3-yl)acetate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 2-(benzyloxycarbonylamino)-2-(oxetan-3-yl)acetate

There total 4 articles about (S)-methyl 2-(benzyloxycarbonylamino)-2-(oxetan-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(benzyloxycarbonylamino)-2-(oxetan-3-yl)acetate (1255717-04-4) → (S)-methyl 2-(benzyloxycarbonylamino)-2-(oxetan-3-yl)acetate (1213783-62-0)

Guidance literature:

With Chiralpak IB; In n-heptane; isopropyl alcohol; Resolution of racemate;

DOI:10.1002/cmdc.201400045

Reference yield:

N-benzyloxycarbonyl-α,β-didehydro-(3-oxetanyl)glycine methyl ester (394653-39-5) → (S)-methyl 2-(benzyloxycarbonylamino)-2-(oxetan-3-yl)acetate (1213783-62-0)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium(II) hydroxide; hydrogen / dichloromethane; methanol / 20 °C

2: sodium carbonate / acetonitrile / 20 °C

3: Chiralpak IB / n-heptane; isopropyl alcohol / Resolution of racemate

With hydrogen; palladium(II) hydroxide; sodium carbonate; In methanol; n-heptane; dichloromethane; isopropyl alcohol; acetonitrile;

DOI:10.1002/cmdc.201400045

Reference yield:

methyl 2-amino-2-(oxetan-3-yl)acetate (394653-40-8,394653-41-9,394653-44-2) → (S)-methyl 2-(benzyloxycarbonylamino)-2-(oxetan-3-yl)acetate (1213783-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / acetonitrile / 20 °C

2: Chiralpak IB / n-heptane; isopropyl alcohol / Resolution of racemate

With sodium carbonate; In n-heptane; isopropyl alcohol; acetonitrile;

DOI:10.1002/cmdc.201400045

upstream raw materials:

methyl 2-(benzyloxycarbonylamino)-2-(oxetan-3-yl)acetate

N-benzyloxycarbonyl-α,β-didehydro-(3-oxetanyl)glycine methyl ester

methyl 2-amino-2-(oxetan-3-yl)acetate

Downstream raw materials:

(S)-benzyl 2-(methylamino)-1-(oxetan-3-yl)-2-oxoethylcarbamate

C₁₃H₁₅NO₅