benzyl 2-{[(tert-butoxy)carbonyl]amino}-4-(3-methoxyphenyl)thiophene-3-carboxylate

Base Information

Chemical Name:benzyl 2-{[(tert-butoxy)carbonyl]amino}-4-(3-methoxyphenyl)thiophene-3-carboxylate
CAS No.:1432511-21-1
Molecular Formula:C₂₄H₂₅NO₅S
Molecular Weight:439.532
Hs Code.:

Synonyms:benzyl 2-{[(tert-butoxy)carbonyl]amino}-4-(3-methoxyphenyl)thiophene-3-carboxylate

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Chemical Property of benzyl 2-{[(tert-butoxy)carbonyl]amino}-4-(3-methoxyphenyl)thiophene-3-carboxylate

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Technology Process of benzyl 2-{[(tert-butoxy)carbonyl]amino}-4-(3-methoxyphenyl)thiophene-3-carboxylate

There total 4 articles about benzyl 2-{[(tert-butoxy)carbonyl]amino}-4-(3-methoxyphenyl)thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1432511-10-8
2-{[(tert-butoxy)carbonyl]amino}-4-(3-methoxyphenyl)thiophene-3-carboxylic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 1432511-21-1
benzyl 2-{[(tert-butoxy)carbonyl]amino}-4-(3-methoxyphenyl)thiophene-3-carboxylate

Guidance literature:: 2-{[(tert-butoxy)carbonyl]amino}-4-(3-methoxyphenyl)thiophene-3-carboxylic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 18h;

benzyl alcohol; In dichloromethane; at 55 ℃;
DOI:10.1016/j.bmcl.2013.03.019

Reference yield:

: 586-37-8
1-(3-Methoxyphenyl)ethanone

: 1432511-21-1
benzyl 2-{[(tert-butoxy)carbonyl]amino}-4-(3-methoxyphenyl)thiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate; acetic acid / toluene / Dean-Stark; Reflux

1.2: 3 h / 50 °C

2.1: dmap / pyridine / 3.17 h / 0 - 55 °C

3.1: potassium hydroxide; water / ethanol / 5 h / Reflux

4.1: 1,1'-carbonyldiimidazole / dichloromethane / 18 h / 20 °C

4.2: 55 °C

With dmap; ammonium acetate; water; acetic acid; 1,1'-carbonyldiimidazole; potassium hydroxide; In pyridine; ethanol; dichloromethane; toluene; 1.1: |Gewald Aminoheterocycles Synthesis / 1.2: |Gewald Aminoheterocycles Synthesis;
DOI:10.1016/j.bmcl.2013.03.019

Reference yield:

: 312289-23-9
ethyl 2-amino-4-(3-methoxyphenyl)thiophene-3-carboxylate

: 1432511-21-1
benzyl 2-{[(tert-butoxy)carbonyl]amino}-4-(3-methoxyphenyl)thiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / pyridine / 3.17 h / 0 - 55 °C

2.1: potassium hydroxide; water / ethanol / 5 h / Reflux

3.1: 1,1'-carbonyldiimidazole / dichloromethane / 18 h / 20 °C

3.2: 55 °C

With dmap; water; 1,1'-carbonyldiimidazole; potassium hydroxide; In pyridine; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2013.03.019