N-(2-Morpholinoethyl)-2-phenylquinazolin-4-amine

Base Information

Chemical Name:N-(2-Morpholinoethyl)-2-phenylquinazolin-4-amine
CAS No.:18602-70-5
Molecular Formula:C₂₀H₂₂N₄O
Molecular Weight:334.421
Hs Code.:
European Community (EC) Number:661-917-5
ChEMBL ID:CHEMBL3580419

Synonyms:N-(2-Morpholinoethyl)-2-phenylquinazolin-4-amine;18602-70-5;Oprea1_647842;SCHEMBL1085597;CHEMBL3580419;BDBM533254;N-(2-(4-MORPHOLINYL)ETHYL)-2-PHENYL-4-QUINAZOLINAMINE;MFCD02333254;US11220486, Compound I184;AKOS001391373;CCG-110994;UPCMLD0ENAT5823183:001;NCGC00301590-01;AB01127292-02;SR-01000110401;SR-01000110401-1;Z31239486;(2-morpholin-4-ylethyl)(2-phenylquinazolin-4- yl)amine;N-[2-(morpholin-4-yl)ethyl]-2-phenylquinazolin-4-amine

Suppliers and Price of N-(2-Morpholinoethyl)-2-phenylquinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of N-(2-Morpholinoethyl)-2-phenylquinazolin-4-amine

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:334.17936134
Heavy Atom Count:25
Complexity:395

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COCCN1CCNC2=NC(=NC3=CC=CC=C32)C4=CC=CC=C4

Technology Process of N-(2-Morpholinoethyl)-2-phenylquinazolin-4-amine

There total 5 articles about N-(2-Morpholinoethyl)-2-phenylquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 6484-25-9
4-chloro-2-phenylquinazoline

: 18602-70-5
(2-morpholin-4-ylethyl)(2-phenylquinazolin-4-yl)amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; Reflux;
DOI:10.1016/j.bmcl.2018.11.041

Reference yield:

: 118-48-9
isatoic anhydride

: 18602-70-5
(2-morpholin-4-ylethyl)(2-phenylquinazolin-4-yl)amine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; ammonium hydroxide / water; acetonitrile / 1 h / 20 °C

2: sodium hydrogensulfite / N,N-dimethyl acetamide / 2 h / 150 °C

3: trichlorophosphate / 16 h / 115 °C

4: isopropyl alcohol / 0.08 h / 80 °C / Microwave irradiation

With ammonium hydroxide; sodium hydrogensulfite; triethylamine; trichlorophosphate; In N,N-dimethyl acetamide; water; isopropyl alcohol; acetonitrile;
DOI:10.2174/1573406414666181005145042

Reference yield:

: 28144-70-9,88-68-6
anthranilic acid amide

: 18602-70-5
(2-morpholin-4-ylethyl)(2-phenylquinazolin-4-yl)amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogensulfite / N,N-dimethyl acetamide / 2 h / 150 °C

2: trichlorophosphate / 16 h / 115 °C

3: isopropyl alcohol / 0.08 h / 80 °C / Microwave irradiation

With sodium hydrogensulfite; trichlorophosphate; In N,N-dimethyl acetamide; isopropyl alcohol;
DOI:10.2174/1573406414666181005145042