1-[2-(Diethoxy-phosphoryl)-acetoxymethyl]-2-oxo-cyclohexanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 1-[2-(Diethoxy-phosphoryl)-acetoxymethyl]-2-oxo-cyclohexanecarboxylic acid ethyl ester
• CAS No.: 139578-19-1
• Molecular Formula: C₁₆H₂₇O₈P
• Molecular Weight: 378.359
• Mol file: 139578-19-1.mol

Synonyms:1-[2-(Diethoxy-phosphoryl)-acetoxymethyl]-2-oxo-cyclohexanecarboxylic acid ethyl ester

Chemical Property of 1-[2-(Diethoxy-phosphoryl)-acetoxymethyl]-2-oxo-cyclohexanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-[2-(Diethoxy-phosphoryl)-acetoxymethyl]-2-oxo-cyclohexanecarboxylic acid ethyl ester

There total 2 articles about 1-[2-(Diethoxy-phosphoryl)-acetoxymethyl]-2-oxo-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

diethyl (2-chloro-2-oxoethyl)phosphonate (34170-81-5) + ethyl 1-(hydroxymethyl)-2-oxocyclohexanecarboxylate (133295-89-3) → 1-[2-(Diethoxy-phosphoryl)-acetoxymethyl]-2-oxo-cyclohexanecarboxylic acid ethyl ester (139578-19-1)

Guidance literature:

With triethylamine; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.39.2797

Reference yield:

ethyl 2-oxocyclohexane carboxylate (1655-07-8) → 1-[2-(Diethoxy-phosphoryl)-acetoxymethyl]-2-oxo-cyclohexanecarboxylic acid ethyl ester (139578-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / NEt₃ / methanol; H₂O / Ambient temperature

2: 97 percent / NEt₃ / CH₂Cl₂ / 0.5 h / Ambient temperature

With triethylamine; In methanol; dichloromethane; water;

DOI:10.1248/cpb.39.2797

upstream raw materials:

diethyl (2-chloro-2-oxoethyl)phosphonate

ethyl 1-(hydroxymethyl)-2-oxocyclohexanecarboxylate

ethyl 2-oxocyclohexane carboxylate