7-(4-fluoro-2-methyl-phenyl)-6-methyl-benzo[1,2,4]triazin-3-ylamine

Base Information

• Chemical Name: 7-(4-fluoro-2-methyl-phenyl)-6-methyl-benzo[1,2,4]triazin-3-ylamine
• CAS No.: 929194-51-4
• Molecular Formula: C₁₅H₁₃FN₄
• Molecular Weight: 268.293
• Mol file: 929194-51-4.mol

Synonyms:7-(4-fluoro-2-methyl-phenyl)-6-methyl-benzo[1,2,4]triazin-3-ylamine

Chemical Property of 7-(4-fluoro-2-methyl-phenyl)-6-methyl-benzo[1,2,4]triazin-3-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(4-fluoro-2-methyl-phenyl)-6-methyl-benzo[1,2,4]triazin-3-ylamine

There total 4 articles about 7-(4-fluoro-2-methyl-phenyl)-6-methyl-benzo[1,2,4]triazin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

7-bromo-6-methylbenzo[e][1,2,4]triazin-3-amine (867333-38-8) + 4-fluoro-2-methylphenylboronic acid (139911-29-8) → 7-(4-fluoro-2-methyl-phenyl)-6-methyl-benzo[1,2,4]triazin-3-ylamine (929194-51-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; ethanol; water; for 3h; Heating;

DOI:10.1016/j.bmcl.2006.11.006

Reference yield:

7-bromo-6-methyl-1-oxy-benzo[1,2,4]triazin-3-ylamine (929194-27-4) → 7-(4-fluoro-2-methyl-phenyl)-6-methyl-benzo[1,2,4]triazin-3-ylamine (929194-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Raney Ni / ethanol / 4 h / 22 °C

2: 80 percent / Pd(PPh₃)4; K₂CO₃ / 1,2-dimethoxy-ethane; ethanol; H₂O / 3 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; potassium carbonate; nickel; In 1,2-dimethoxyethane; ethanol; water; 2: Suzuki coupling;

DOI:10.1016/j.bmcl.2006.11.006

Reference yield:

N-(4-bromo-5-methyl-2-nitro-phenyl)-guanidine → 7-(4-fluoro-2-methyl-phenyl)-6-methyl-benzo[1,2,4]triazin-3-ylamine (929194-51-4)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaOH / 0.5 h / 110 °C

2: H₂ / Raney Ni / ethanol / 4 h / 22 °C

3: 80 percent / Pd(PPh₃)4; K₂CO₃ / 1,2-dimethoxy-ethane; ethanol; H₂O / 3 h / Heating

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; potassium carbonate; nickel; In 1,2-dimethoxyethane; ethanol; water; 3: Suzuki coupling;

DOI:10.1016/j.bmcl.2006.11.006

upstream raw materials:

7-bromo-6-methylbenzo[e][1,2,4]triazin-3-amine

4-fluoro-2-methylphenylboronic acid

7-bromo-6-methyl-1-oxy-benzo[1,2,4]triazin-3-ylamine

4-bromo-5-methyl-2-nitrophenylamine