2-Pyrrolidinecarboxamide,N-hydroxy-,(2S)-(9CI)

Base Information

• Chemical Name: 2-Pyrrolidinecarboxamide,N-hydroxy-,(2S)-(9CI)
• CAS No.: 31982-81-7
• Molecular Formula: C₅H₁₀N₂O₂
• Molecular Weight: 130.147
• Mol file: 31982-81-7.mol

Synonyms:2-Pyrrolidinecarbohydroxamicacid, L- (8CI); 2-Pyrrolidinecarboxamide, N-hydroxy-, (S)-; L-Prolylhydroxamicacid

Chemical Property of 2-Pyrrolidinecarboxamide,N-hydroxy-,(2S)-(9CI)

Chemical Property:

• Melting Point: 68-69 °C
• PKA: 8.28±0.23(Predicted)
• PSA: 61.36000
• Density: 1.229±0.06 g/cm3(Predicted)
• LogP: -0.03650

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyrrolidinecarboxamide,N-hydroxy-,(2S)-(9CI)

There total 6 articles about 2-Pyrrolidinecarboxamide,N-hydroxy-,(2S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-CBZ-O-Benzylproline hydroxamate → L-proline hydroxamic acid (31982-81-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;

DOI:10.1021/jo00129a059

Reference yield: 99.0%

(S)-2-Benzyloxycarbamoyl-pyrrolidine-1-carboxylic acid benzyl ester; hydrochloride → L-proline hydroxamic acid (31982-81-7)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethanol; for 0.5h;

DOI:10.1021/ol0618407

Reference yield: 88.0%

methyl (2S)-pyrrolidine carboxylate (2577-48-2) → L-proline hydroxamic acid (31982-81-7)

Guidance literature:

With potassium hydroxide; hydroxylamine hydrochloride; In methanol; at 80 ℃; for 0.1h; microwave irradiation;

DOI:10.1055/s-2007-990803

upstream raw materials:

N-Benzyloxycarbonyl-L-proline

N-carbobenzyloxy-L-proline methyl ester

methyl (2S)-pyrrolidine carboxylate

(S)-N-(tert-butoxycarbonyl)proline methyl ester