N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

Base Information

Chemical Name:N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide
CAS No.:737824-46-3
Molecular Formula:C₂₁H₂₃N₃O₃S₂
Molecular Weight:429.564
Hs Code.:

Synonyms:N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

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Chemical Property of N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

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Technology Process of N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

There total 13 articles about N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 737824-53-2
N-{5-[4-(methylsulfonyl)benzyl]-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide

: 737824-46-3
N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

Guidance literature:: N-{5-[4-(methylsulfonyl)benzyl]-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide; With palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran; methanol; at 20 ℃; for 3h; under 2280.15 Torr;

With sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 737824-50-9
ethyl 2-(acetylamino)-5-[4-(methylthio)benzyl]-1,3-thiazole-4-carboxylate

: 737824-46-3
N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: manganese(IV) oxide / methanol; chloroform / 13 h / 20 °C / Inert atmosphere

3: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4: Oxone / water; tetrahydrofuran / 0 - 20 °C

5: acetic acid; palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C / 2280.15 Torr

With manganese(IV) oxide; Oxone; lithium aluminium tetrahydride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; acetic acid; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide; 3: |Wittig Olefination;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 737824-51-0
N-{4-formyl-5-[4-(methylthio)benzyl]-1,3-thiazol-2-yl}acetamide

: 737824-46-3
N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: Oxone / water; tetrahydrofuran / 0 - 20 °C

3: acetic acid; palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C / 2280.15 Torr

With Oxone; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; acetic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 1: |Wittig Olefination;
DOI:10.1016/j.bmc.2013.02.048