5-[4-(TRIFLUOROMETHOXY)PHENYL]-2-FURALDEHYDE

Base Information

• Chemical Name: 5-[4-(TRIFLUOROMETHOXY)PHENYL]-2-FURALDEHYDE
• CAS No.: 306935-95-5
• Molecular Formula: C12H7 F3 O3
• Molecular Weight: 256.181
• Hs Code.: 2932190090
• Mol file: 306935-95-5.mol

Synonyms:5-[4-(Trifluoromethoxy)phenyl]-2-furaldehyde

Chemical Property of 5-[4-(TRIFLUOROMETHOXY)PHENYL]-2-FURALDEHYDE

Chemical Property:

• Vapor Pressure: 0.000409mmHg at 25°C
• Melting Point: 87 °C
• Refractive Index: 1.513
• Boiling Point: 316.5°Cat760mmHg
• Flash Point: 145.2°C
• PSA: 39.44000
• Density: 1.351g/cm³
• LogP: 3.65770

Purity/Quality:

98%min ^*data from raw suppliers

5-[4-(TRIFLUOROMETHOXY)PHENYL]-2-FURALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-[4-(TRIFLUOROMETHOXY)PHENYL]-2-FURALDEHYDE

There total 4 articles about 5-[4-(TRIFLUOROMETHOXY)PHENYL]-2-FURALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-bromo-2-furancarboxaldehyde (1899-24-7) + 4-trifluoromethoxyphenylboronic acid (139301-27-2) → 5-(4-trifluoromethoxyphenyl) furan-2-formaldehyde (306935-95-5)

Guidance literature:

With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; for 5h; Heating;

DOI:10.1016/j.bmc.2004.07.010

Reference yield:

furfural (98-01-1) + C7H5F3N2O*ClH → 5-(4-trifluoromethoxyphenyl) furan-2-formaldehyde (306935-95-5)

Guidance literature:

With copper dichloride; In acetone; at 20 ℃; for 12h;

DOI:10.1007/s00044-013-0648-7

Reference yield:

furfural (98-01-1) + 4-(trifluoromethoxy)aniline (461-82-5) → 5-(4-trifluoromethoxyphenyl) furan-2-formaldehyde (306935-95-5)

Guidance literature:

4-(trifluoromethoxy)aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

furfural; With copper dichloride; In acetone; at 20 ℃; for 12h;

DOI:10.1016/j.bioorg.2020.104483

upstream raw materials:

5-bromo-2-furancarboxaldehyde

4-trifluoromethoxyphenylboronic acid

furfural

4-(trifluoromethoxy)aniline

Downstream raw materials:

3-[5-(4-trifluoromethoxyphenyl)-2-furyl]acrylic acid

2-(4-((5-(4-trifluoromethoxyphenyl)furan-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid