2-(tert-butoxy)-2-(1-(2-((4-fluorophenyl)amino)-2-oxoethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

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Chemical Name:2-(tert-butoxy)-2-(1-(2-((4-fluorophenyl)amino)-2-oxoethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid
CAS No.:1428794-08-4
Molecular Formula:C₂₉H₃₀FN₃O₅
Molecular Weight:519.573
Hs Code.:

Synonyms:2-(tert-butoxy)-2-(1-(2-((4-fluorophenyl)amino)-2-oxoethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

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Chemical Property of 2-(tert-butoxy)-2-(1-(2-((4-fluorophenyl)amino)-2-oxoethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

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Technology Process of 2-(tert-butoxy)-2-(1-(2-((4-fluorophenyl)amino)-2-oxoethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

There total 9 articles about 2-(tert-butoxy)-2-(1-(2-((4-fluorophenyl)amino)-2-oxoethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₂FN₃O₅

: 1428794-08-4
2-(tert-butoxy)-2-(1-(2-((4-fluorophenyl)amino)-2-oxoethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

Guidance literature:: C₃₀H₃₂FN₃O₅; With methanol; lithium hydroxide; In tetrahydrofuran; at 70 ℃; for 1.33333h;

With trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: methyl 2-(tert-butoxy)-2-(1-(2-(tert-butoxy)-2-oxoethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetate

: 1428794-08-4
2-(tert-butoxy)-2-(1-(2-((4-fluorophenyl)amino)-2-oxoethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

2: perchloric acid / 2 h / 20 °C

3: lithium hydroxide; methanol / tetrahydrofuran / 1.33 h / 70 °C

With methanol; perchloric acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1428793-92-3
2-(1-benzyl-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)-2-(tert-butoxy)acetic acid

: 1428794-08-4
2-(tert-butoxy)-2-(1-(2-((4-fluorophenyl)amino)-2-oxoethyl)-6-methyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.67 h / 0 °C

1.2: pH 2

2.1: methanol / 0.17 h / 20 °C

3.1: caesium carbonate / acetonitrile / 1 h / 80 °C / Sealed tube

4.1: trifluoroacetic acid / dichloromethane / 60 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.1: perchloric acid / 2 h / 20 °C

7.1: lithium hydroxide; methanol / tetrahydrofuran / 1.33 h / 70 °C

With methanol; perchloric acid; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; n-heptane; dichloromethane; ethylbenzene; N,N-dimethyl-formamide; acetonitrile;