3-AMINO-5-METHYL-4-PHENYLPYRAZOLE

Base Information

• Chemical Name: 3-AMINO-5-METHYL-4-PHENYLPYRAZOLE
• CAS No.: 31924-81-9
• Molecular Formula: C10H11N3
• Molecular Weight: 173.217
• Mol file: 31924-81-9.mol

Synonyms:3-AMINO-5-METHYL-4-PHENYLPYRAZOLE;5-METHYL-4-PHENYL-1H-PYRAZOLE-3-YLAMINE

Chemical Property of 3-AMINO-5-METHYL-4-PHENYLPYRAZOLE

Chemical Property:

• Melting Point: 140-142 °C
• Boiling Point: 368.5 °C at 760 mmHg
• PKA: 15.78±0.50(Predicted)
• Flash Point: 204.3 °C
• PSA: 54.70000
• Density: 1.196 g/cm³
• LogP: 2.54850

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-4-phenyl-2H-pyrazol-3-ylamine 97+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Methyl-4-phenyl-2H-pyrazol-3-ylamine can be used to diagnose and treat cardiovascular diseases and conditions.

Technology Process of 3-AMINO-5-METHYL-4-PHENYLPYRAZOLE

There total 6 articles about 3-AMINO-5-METHYL-4-PHENYLPYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-Amino-3-methyl-4-phenyl-1H-pyrazol-1-carbonsaeure-methylester (109013-33-4) → 3-amino-5-methyl-4-phenyl-1Н-pyrazole (31924-81-9)

Guidance literature:

With isopropylamine; In methanol; for 3h; Ambient temperature;

Reference yield: 89.0%

4-phenyl-semicarbazide (537-47-3) + 5-Amino-3-methyl-N,4-diphenyl-1H-pyrazol-1-carboxamid (109013-19-6) → 1-phenylcarbamoyl-4-phenyl semicarbazide (2937-77-1) + 3-amino-5-methyl-4-phenyl-1Н-pyrazole (31924-81-9)

Guidance literature:

In dichloromethane; for 96h; Ambient temperature;

Reference yield: 73.0%

1-phenyl-1-cyanopropan-2-one (4468-48-8) → 3-amino-5-methyl-4-phenyl-1Н-pyrazole (31924-81-9)

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; at 50 ℃; for 7h; Reflux;

DOI:10.1134/S1070428014030191

upstream raw materials:

4-phenyl-semicarbazide

5-Amino-3-methyl-N,4-diphenyl-1H-pyrazol-1-carboxamid

1-phenyl-1-cyanopropan-2-one

5-Amino-3-methyl-4-phenyl-1H-pyrazol-1-carbonsaeure-methylester

Downstream raw materials:

3-(4-Chlorphenyl)-7-methyl-8-phenyl-pyrazolo<5,1-d>-1,2,3,5-tetrazin-4(3H)-on

7-Methyl-3,8-diphenyl-pyrazolo<5,1-d>-1,2,3,5-tetrazin-4(3H)-on

5-Amino-3-methyl-N,4-diphenyl-1H-pyrazol-1-carboxamid

2-Methyl-3,5,7-triphenyl-pyrazolo[1,5-a]pyrimidine

Refernces

Synthesis of new azocompounds and fused pyrazolo[5,1-c][1,2,4]triazines using heterocyclic components

10.1002/jhet.1533

The study, titled "Synthesis of New Azocompounds and Fused Pyrazolo[5,1-c][1,2,4]triazines Using Heterocyclic Components," investigates the synthesis of new azocompounds and tricyclic pyrazolo[5,1-c][1,2,4]triazines using various heterocyclic components. The key chemical involved is 3-methyl-4-phenyl-1H-pyrazol-5-amine, which is diazotized to form pyrazole-3(5)-diazonium chloride. This diazonium salt undergoes azocoupling reactions with a variety of heterocyclic compounds, including barbituric acid, thiobarbituric acid, 2-hetarylpyrimidine-4,6-diones, 4-hydroxy-6-methylpyridin-2(1H)-one, 4-hydroxy-6-methyl-2H-pyran-2-one, 4-hydroxy-1-p-tolyl-1H-pyrazole-3-carboxylic acid ethyl ester, 1,3-thiazolidine-2,4-dione, and 2-thioxo-1,3-thiazolidin-4-one. These reactions yield new pyrazolylazo derivatives and fused pyrazolo[5,1-c][1,2,4]triazines through subsequent heterocyclization processes. The study explores the synthetic potential of these heterocyclic components in azocoupling reactions, highlighting their potential applications in industrial azo dyes, analytical indicators, and bioactive compounds related to purines.